Pracownia Neurobiologii

Dalekosiężnym celem naszych badań jest poznanie relacji mózg-umysł. Uważamy, że można zlokalizować w mózgu czynności umysłu oraz wyjaśnić ich molekularne i komórkowe podłoże. Podglądamy te zjawiska przez okno jakie tworzą uczenie się i pamięć, które można skutecznie poznawać u zwierząt doświadczalnych. Uważamy, że podstawą tych procesów jest tzw. plastyczność synaptyczna, czyli zmiany siły połączeń między komórkami nerwowymi w mózgu. Zmiany te zaś określają funkcjonowanie sieci neuronalnych, przechowujących, przenoszących i modyfikujących informacje. Ponad 25 lat temu odkryliśmy zjawisko zmian aktywności genów w komórkach nerwowych w mózgu w wyniku uczenia się i tworzenia pamięci długotrwałej. Zaobserwowane wówczas zmiany ekspresji genu c-fos, który koduje składnik regulatora aktywności genów, czyli czynnika transkrypcyjnego, zwanego AP-1 zainicjowały poszukiwania genów kontrolowanych przez AP-1 i doprowadziły nas do układu enzymów proteolitycznych macierzy zewnątrzkomórkowej na synapsie pobudzającej. W szczególności nasze dzisiejsze badania ogniskują się wokół MMP-9 (ang. Matrix metalloproteinase-9), metaloproteazy macierzowej. Odkryliśmy jej synaptyczne występowanie, lokalną translację i wydzielenie po pobudzeniu komórki nerwowej. Zidentyfikowaliśmy niektóre substraty. Wykazaliśmy także ważny udział MMP-9 w plastyczności synaptycznej, uczeniu się i pamięci. Obecnie badamy zwłaszcza uczenie apetytywne, czyli prowadzące do zapamiętania zdarzeń przyjemnych. Odkryliśmy, że pewna struktura mózgu, tzw. jądro środkowe ciała migdałowatego odgrywa tu wielką rolę.

2022

2021

Kopczyńska K, Średnicka-Tober D, Hallmann E, Wilczak J, Wasiak-Zys G, Wyszyński Z, Kucińska K, Perzanowska A, Szacki P, Barański M, Gawron P, Góralska-Walczak R, Rembiałkowska E, Kazimierczak R. Bioactive Compounds, Sugars, and Sensory Attributes of Organic and Conventionally Produced Courgette (Cucurbita pepo). Foods, 10: 2475, 2021
Mielnicka A, Michaluk P. Exocytosis in Astrocytes. Biomolecules, 11, 1367, 2021.
Sosnowska A, Chlebowska-Tuz J, Matryba P, Pilch Z, Greig A, Wolny A, Grzywa TM, Rydzynska Z, Sokolowska O, Rygiel TP, Grzybowski M, Stanczak P, Blaszczyk R, Nowis D, Golab J. Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma. Oncoimmunology. 10: 1956143, 2021.
Pankiewicz P, Szybiński M, Kisielewska K, Gołębiowski F, Krzemiński P, Rutkowska-Włodarczyk I, Moszczyński-Pętkowski R, Gurba-Bryśkiewicz L, Delis M, Mulewski K, Smuga D, Dominowski J, Janusz A, Górka M, Abramski K, Napiórkowska A, Nowotny M, Dubiel K, Kalita K, Wieczorek M, Pieczykolan J, Matłoka M. Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists. Pharmaceuticals (Basel), 14: 704, 2021.
Ziarniak K, Dudek M, Matuszewska J, Bijoch Ł, Skrzypski M, Celichowski J, Sliwowska JH. Two weeks of moderate intensity locomotor training increased corticosterone concentrations but did not alter the number of adropin-immunoreactive cells in the hippocampus of diabetic type 2 and control rats. Acta Histochemica, 123: 151751, 2021.
Mazuryk J, Puchalska I, Koziński K, Ślusarz MJ, Ruczyński J, Rekowski P, Rogujski P, Płatek R, Wiśniewska MB, Piotrowski A, Janus Ł, Skowron PM, Pikuła M, Sachadyn P, Rodziewicz-Motowidło S, Czupryn A, Mucha P. PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke. International Journal of Molecular Sciences, 22: 6086, 2021.
Matryba P., Łukasiewicz K., Pawłowska M., Tomczuk J., Gołąb J. Can developments in tissue optical clearing aid super-resolution microscopy imaging? International Journal of Molecular Sciences, 22: 6730, 2021.
Iman IN,, Yusof NAM, Talib UM, Ahmad NUZ, Norazit A, Kumar J, Mehat MZ, Jayabalan N, Sangu M, Stefaniuk M, Kaczmarek L, Muzaimi M. The IntelliCage system: A review of its utility as a novel behavioral platform for rodent model of substance use disorder. Frontiers in Behavioral Neuroscience, 15: 683780, 2021.
Kaczmarek L. Obituary: GRZEGORZ WILCZYŃSKI (1971–2020). Acta Neurobiologiae Experimentalis 81: i–ii, 2021.
Wang J, Barański M, Hasanaliyeva G, Korkut R, Kalee HA, Leifert A, Winter S, Janovska D, Willson A, Barkla B, Iversen PO, Seal C, Bilsborrow P, Leifert C, Rempelos L, Volakakis N. Effect of irrigation, fertiliser type and variety on grain yield and nutritional quality of spelt wheat (Triticum spelta) grown under semi-arid conditions. Food Chemistry, 358: 129826, 2021.
Michaluk P, Heller JP, Rusakov DA. Rapid recycling of glutamate transporters on the astroglial surface. Elife, 10: e64714, 2021.
Hasanaliyeva G, Chatzidimitrou E, Wang J, Baranski M, Volakakis N, Pakos P, Seal C, Rosa EAS, Markellou E, Iversen PO, Vigar V, Willson A, Barkla B, Leifert C, Rempelos L. Effect of organic and conventional production methods on fruit yield and nutritional quality parameters in three traditional cretan grape varieties: Results from a farm survey. Foods, 10: 476, 2021.
Matusiak M., Oziębło D., Obrycka A., Ołdak M., Kaczmarek L., Skarzynski P.H., Skarżyński H. Functional polymorphism of MMP9 and BDNF as potential biomarker of auditory neuroplasticity in prelingual deafness treatment with cochlear implantation – a retrospective cohort analysis. Trends in Hearing, 25:1-13, 2021.
Salamian A., Legutko D., Nowicka K., Badyra B., Kaźmierska-Grębowska P., Caban B., Kowalczyk T., Kaczmarek L., Beroun A. Inhibition of matrix metalloproteinase 9 activity promotes synaptogenesis in the hippocampus. Cerebral Cortex, 31: 3161-3163, 2021.
Barański M, Średnicka-Tober D, Rempelos L, Hasanaliyeva G, Gromadzka-Ostrowska J, Skwarło-Sońta K, Królikowski T, Rembiałkowska E, Hajslova J, Schulzova V, Cakmak I, Ozturk L, Hallmann E, Seal C, Iversen PO, Vigar V, Leifert C. Feed composition differences resulting from organic and conventional farming practices affect physiological parameters in Wistar rats-results from a factorial, two-generation dietary intervention trial. Nutrients, 13: 377, 2021.
Liszewska E., Majchrowicz L., Krogulec E., Kotulska K., Kaczmarek L., Kalita K., Dobrzyń A., Jaworski J. Establishment of two hiPSC lines (IIMCBi001-A and IIMCBi002-A) from dermal fibroblasts of healthy donors and characterization of their cell cycle. Stem Cell Research, 52: 102225, 2021.
Szczepankiewicz D, Celichowski P, Kołodziejski PA, Pruszyńska-Oszmałek E, Sassek M, Zakowicz P, Banach E, Langwiński W, Sakrajda K, Nowakowska J, Socha M, Bukowska-Olech E, Pawlak J, Twarowska-Hauser J, Nogowski L, Rybakowski JK, Szczepankiewicz A. Transcriptome changes in three brain regions during chronic lithium administration in the rat models of mania and depression. International Journal of Molecular Sciences, 22: 1148, 2021.
Cały A, Śliwińska MA, Ziółkowska M, Łukasiewicz K, Pagano R, Dzik JM, Kalita K, Bernaś T, Stewart MG, Giese KP, Radwanska K. PSD-95 in CA1 area regulates spatial choice depending on age. Journal of Neuroscience, 41: 2329-2343, 2021.
Figiel I., Kruk P.K., Zareba-Kozioł M., Rybak P., Bijata M., Wlodarczyk J., Dzwonek J. MMP-9 signaling pathways that engage Rho GTPases in brain plasticity. Cells, 10: 166, 2021.
Pekala M., Doliwa M., Kalita K. Impact of maternal immune activation on dendritic spine development. Developmental Neurobiology, in press.
Hernaiz-Llorens M, Roselló-Busquets C, Durisic N, Filip A, Ulloa F, Martínez-Mármol R, Soriano E. Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors. Cellular and Molecular Life Sciences, 78: 2797-2820, 2021

2020

Pijet B., Konopka A., Rejmak E., Stefaniuk M., Khomiak D., Bulska E., Pikul S., Kaczmarek L. The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus. Scientific Reports, 10: 21314, 2020.
Shahbazi S, Zakerali T, Frycz BA, Kaur J. The critical role of piperamide derivative D4 in the regulation of inflammatory response by the microglia and astrocytic glial cells. Biomedicine & Pharmacotherapy, 132: 110895, 2020.
Czajkowski R., Zglinicki B., Rejmak E., Konopka W. Strategy-specific patterns of Arc expression in retrosplenial cortex and hippocampus during T-maze learning in rats. Brain Sciences, 10: E854. 2020.
Llamosas N, Arora V, Vij R, Kilinc M, Bijoch L, Rojas C, Reich A, Sridharan B, Willems E, Piper DR, Scampavia L, Spicer TP, Miller CA, Holder JL Jr, Rumbaugh G SYNGAP1 controls the maturation of dendrites, synaptic function, and network activity in developing human neurons. Journal of Neuroscience, 40: 7980-7994, 2020.
Lipiec MA, Bem J, Koziński K, Chakraborty C, Urban-Ciećko J, Zajkowski T, Dąbrowski M, Szewczyk ŁM, Toval A, Ferran JL, Nagalski A, Wiśniewska MB. TCF7L2 regulates postmitotic differentiation programs and excitability patterns in the thalamus. Development, 147: dev190181, 2020.
Sawicka J, Dzierżyńska M, Wardowska A, Deptuła M, Rogujski P, Sosnowski P, Filipowicz N, Mieczkowska A, Sass P, Pawlik A, Hać A, Schumacher A, Gucwa M, Karska N, Kamińska J, Płatek R, Mazuryk J, Zieliński J, Kondej K, Młynarz P, Mucha P, Skowron P, Janus Ł, Herman-Antosiewicz A, Sachadyn P, Czupryn A, Piotrowski A, Pikuła M, Rodziewicz-Motowidło S. Imunofan-RDKVYR peptide-stimulates skin cell proliferation and promotes tissue repair. Molecules, 25: E2884. 2020
Skóra MN, Pattij T, Beroun A, Kogias G, Mielenz D, de Vries T, Radwanska K, Müller CP. Personality driven alcohol and drug abuse: new mechanisms revealed. Neuroscience & Biobehavioral Reviews, 116: 64-73, 2020.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I. Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas. Stem Cell Research & Therapy, 11: 238, 2020.
Grzywa TM, Sosnowska A, Matryba P, Rydzynska Z, Jasinski M, Nowis D, Golab J. Myeloid cell-derived arginase in cancer immune response. Frontiers in Immunology, 11: 938, 2020.
Shahbazi S, Zakerali T, Frycz B, Kaur J. Impact of novel N-aryl substituted piperamide on NF-kappa B translocation as a potent anti-neuroinflammatory agent. Biomedicine & Pharmacotherapy, 127: 110199, 2020.
Szczepankiewicz D, Narożna B, Celichowski P, Sakrajda K, Kołodziejski P, Banach E, Zakowicz P, Pruszyńska-Oszmałek E, Pawlak J, Wiłkość M, Dmitrzak-Węglarz M, Skibińska M, Bejger A, Twarowska-Hauser J, Rybakowski JK, Nogowski L, Szczepankiewicz A. Genes involved in glucocorticoid receptor signaling affect susceptibility to mood disorders. World Journal of Biological Psychiatry, 13: 1-32, 2020.
Gorlewicz A, Krawczyk K, Szczepankiewicz AA, Trzaskoma P, Mulle C, Wilczynski GM. Colocalization Colormap - an ImageJ plugin for the quantification and visualization of colocalized signals. Neuroinformatics, 18: 661-664, 2020.
Matryba P, Wolny A, Pawłowska M, Sosnowska A, Rydzyńska Z, Jasiński M, Stefaniuk M, Gołąb J. Tissue clearing-based method for unobstructed 3D imaging of mouse penis with subcellular resolution. Journal of Biophotonics, e202000072, 2020.
Kiryk A., Janusz A., Zgnilicki B., Turkes E., Knapska E., Konopka W., Lipp H.-P., Kaczmarek L. IntelliCage as a tool for measuring mouse behavior – 20 years perspective. Behavioural Brain Research, 388: 112620, 2020.
Deptuła M., Karpowicz P., Wardowska A., Sass P., Sosnowski P., Mieczkowska A., Filipowicz N., Dzierżyńska M., Sawicka J., Nowicka E., Langa P., Schumacher A., Cichorek M., Zieliński J., Kondej K., Kasprzykowski F., Czupryn A., Janus L., Mucha P., Skowron P., Piotrowski A., Sachadyn P., Rodziewicz-Motowidło S., Pikula M. Development of a peptide derived from Platelet-Derived Growth Factor (PDGF-BB) into a potential drug candidate for the treatment of wounds. Advances in Wound Care (New Rochelle), 9: 657-675, 2020.
Matryba P., Sosnowska A., Wolny A., Bozycki L., Greig A., Grzybowski J., Stefaniuk M., Nowis D., Gołąb. J. Systematic evaluation of chemically distinct tissue optical clearing techniques in murine lymph nodes. Journal of Immunology, 204: 1395-1407, 2020.
Skowron PM, Krawczun N, Żebrowska J, Krefft D, Żołnierkiewicz O, Bielawa M, Jeżewska-Frąckowiak J, Janus Ł, Witkowska M, Palczewska M, Schumacher A, Wardowska A, Deptuła M, Czupryn A, Mucha P, Piotrowski A, Sachadyn P, Rodziewicz-Motowidło S, Pikuła M, Zylicz-Stachula A. Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method. Data Brief, 28: 105069, 2020.
Skowron PM, Krawczun N, Zebrowska J, Krefft D, Zołnierkiewicz O, Bielawa M, Jezewska-Frackowiak J, Janus L, Witkowska M, Palczewska M, Schumacher A, Wardowska A, Deptula M, Czupryn A, Mucha P, Piotrowski A, Sachadyn P, Rodziewicz-Motowidlo S, Pikula M, Zylicz-Stachula A. A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications. Materials Science and Engineering: C Materials for Biological Applications 108:110426, 2020.
Young C.N.J., Gosselin M.R.F., Rumney R., Oksiejuk A., Chira N., Bozycki L., Matryba P., Łukasiewicz K., Kao P.A., Dunlop J., Robson S.C., Zabłocki K., Górecki D.C. Total absence of dystrophin expression exacerbates ectopic myofiber calcification, fibrosis, and alters macrophage infiltration patterns. American Journal of Pathology, 190: 190-205, 2020.
Prades R., Bertran A., Khomiak D., Konopka A., Rejmak E., Bulska E., Seco J., Kaczmarek L., Tarragó T. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorganic Chemistry, 94: 103365, 2020.

2019

Vafadari B., Mitra S., Stefaniuk M., Kaczmarek L. Psychosocial stress induces schizophrenia-like-behavior in mice with reduced MMP-9 activity. Frontiers in Behavioral Neuroscience, 13: 195, 2019.
Nader K., Krysiak A., Beroun A., Pekala M., Szymanska M., Kuzniewska B., Radwanska K., Kaczmarek L., Kalita K. Loss of serum response factor in mature neurons in the dentate gyrus alters the morphology of dendritic spines and hippocampus-dependent behavioral tasks. Brain Structure & Function, 224: 2691-2701, 2019.
Sass P, Sosnowski P, Podolak-Popinigis J, Górnikiewicz B, Kamińska J, Deptuła M, Nowicka E, Wardowska A, Ruczyński J, Rekowski P, Rogujski P, Filipowicz N, Mieczkowska A, Peszyńska-Sularz G, Janus Ł, Skowron P, Czupryn A, Mucha P, Piotrowski A, Rodziewicz-Motowidło S, Pikuła M, Sachadyn P. Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse. EBioMedicine, 46: 317-329, 2019.
Bijoch Ł, Borczyk M, Czajkowski R. Bases of Jerzy Konorski’s theory of synaptic plasticity. European Journal of Neuroscience, 51: 1857-1866, 2020.
Koza P., Beroun A., Konopka A., Gorkiewicz T., Bijoch L., Torres J.C., Bulska E., Knapska E., Kaczmarek L., Konopka W. Neuronal TDP-43 depletion affects activity-dependent plasticity. Neurobiology of Disease, 130: 104499, 2019.
Beroun A., Mitra S., Michaluk P., Pijet B., Stefaniuk M., Kaczmarek L. MMPs in learning and memory and neuropsychiatric disorders. Cellular and Molecular Life Sciences, 76: 3207-3228, 2019.
Matryba P., Kaczmarek L., Golab J. Advances in ex situ tissue optical clearing. Laser & Photonics Reviews, 13: 1800292, 2019.
Rojek K.O., Krzemien J., Dolezyczek H., Boguszewski P.M., Kaczmarek L., Konopka W., Rylski M, Jaworski J., Holmgren L., Proszynski T.J. Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLOS Biology, 17: e3000253.
Pijet B., Stefaniuk M., Kaczmarek L. MMP-9 contributes to dendritic spine remodeling following traumatic brain injury. Neural Plasticity, Article ID 3259295, 2019.
Bielak-Zmijewska A, Grabowska W, Ciolko A, Bojko A, Mosieniak G, Bijoch Ł, Sikora E. The Role of curcumin in the modulation of ageing. International Journal of Molecular Sciences, 20: 1239, 2019
Urbanska M., Kazmierska-Grebowska P., Kowalczyk T., Caban B., Nader K., Pijet B., Kalita K., Gozdz A., Devijver H., Lechat B., Jaworski T., Grajkowska W., Sadowski K., Jozwiak S., Kotulska K., Konopacki J., Van Leuven F., van Vliet E., Aronica E., Jaworski J. GSK3b activity alleviates epileptogenesis and limits GluA1 phosphorylation. EBioMedicine, 9: 377-387, 2019.
Pawlak A., Rejmak-Kozicka E., Gil K., Ziemba A., Kaczmarek L., Gil RJ. The patterns of desmin expression in idiopathic dilated cardiomyopathy is related to the desmin mRNA and ubiquitin expression. Journal of Investigative Medicine, 67: 11-19, 2019.

1988-2018

2018

Jaworski J., Kalita K., Knapska E., c-Fos and neuronal plasticity: the aftermath of Kaczmarek’s theory Acta Neurobiologiae Experimentalis, 78: 287-296, 2018.
Kaczmarek L. From c-Fos to MMP-9: In control of synaptic plasticity to produce healthy and diseased mind, a personal view. Postepy Biochemii, 64: 101-109, 2018.
Khomiak D., Kaczmarek L. Matrix metalloproteinase 9 and epileptogenesis, the crucial role of the enzyme and strategies to prevent the disease development. Postepy Biochemii, 64: 222-230, 2018.
Gorlewicz A., Kaczmarek L., Pathophysiology of trans-synaptic adhesion molecules: implications for epilepsy. Frontiers in Cell and Developmental Biology, 6: 119, 2018.
Mieczkowska A, Schumacher A, Filipowicz N, Wardowska A, Zieliński M, Madanecki P, Nowicka E, Langa P, Deptuła M, Zieliński J, Kondej K, Renkielska A, Buckley PG, Crossman DK, Crowley MR, Czupryn A, Mucha P, Sachadyn P, Janus Ł, Skowron P, Rodziewicz-Motowidło S, Cichorek M, Pikuła M, Piotrowski A. Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells. Scientific Reports, 8: 11339, 2018.
Banach E, Pawlak J, Kapelski P, Szczepankiewicz A, Rajewska-Rager A, Skibinska M, Czerski P, Twarowska-Hauser J, Dmitrzak-Weglarz M. Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse. Journal of Affective Disorders, 241: 142-146, 2018.
Bozycki L, Łukasiewicz K., Matryba P., Pikula S. Whole-body clearing, staining and screening of calcium deposits in the mdx mouse model of Duchenne muscular dystrophy. Skeletal Muscle, 8: 21, 2018.
Beroun A., Nalberczak-Skóra M., Harda Z., Piechota M., Ziółkowska M., Cały A., Pagano R., Radwanska K. Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction. Neuropsychopharmacology, 43: 1989-1999, 2018.
Mitra S., Ghantasala S., Sameer Kumar GS, Lakshmi BJ, Thakur SS, Kumar S. Absence of Wdr13 gene predisposes mice to mild social isolation - chronic stress, leading to depression-like phenotype associated with differential expression of synaptic proteins. Frontiers in Molecular Neuroscience, 11: 133, 2018.
Pijet B., Stefaniuk M., Kostrzewska-Ksiezyk A., Tsilibary P-E., Tzinia A., Kaczmarek L. Elevation of MMP-9 levels promotes epileptogenesis after traumatic brain injury. Molecular Neurobiology, 55: 9294-9306, 2018.
Matryba P., Bozycki L., Pawłowska M., Kaczmarek L., Stefaniuk M. Optimized perfusion-based CUBIC protocol for the efficient whole-body clearing and imaging of rat organs. Journal of Biophotonics, 11: e201700248, 2018.
Urbanska M, Gozdz A, Macias M, Cymerman IA, Liszewska E, Kondratiuk I, Devijver H, Lechat B, Van Leuven F, Jaworski J. GSK3β controls mTOR and prosurvival signaling in neurons. Molecular Neurobiology, 55: 6050-6062, 2018.
de Hoz L., Gierej D., Lioudyno L., Jaworski J., Blazejczyk M., Cruces-Solís H., Beroun A., Lebitko T., Nikolaev T., Knapska E., Nelken I., Kaczmarek L. Blocking c-Fos expression reveals the role of auditory cortex plasticity in sound frequency discrimination learning. Cerebral Cortex, 28: 1645–1655, 2018.
Winkler D., Daher F., Wüstefeld L., Hammerschmidt K., Poggi G., Seelbach A., Krueger-Burg D., Vafadari B., Ronnenberg A., Liu Y., Kaczmarek L., Schlüter O.M., Ehrenreich H. Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93. Behavioural Brain Research, 2: 35–45, 2018.
Urban-Ciecko J., Jouhanneau J-S., Myal S.E., Poulet J.F.A., and Barth A.L. Precisely-timed nicotinic activation drives SST inhibition in neocortical circuits. Neuron, 97: 611-625, 2018.
Kaneda M, Sakagami H, Hida Y, Ohtsuka T, Satou N, Ishibashi Y, Fukuchi M, Krysiak A, Ishikawa M, Ihara D, Kalita K, Tabuchi A. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology. Scientific Reports, 8: 722018, 2018.
Quattromani M.L, Pruvost M., Guerreiro C., Backlund F., Englund E., Aspberg A., Jaworski T., Hakon J., Ruscher K., Kaczmarek L., Vivien D., Wieloch T. Extracellular matrix modulation is driven by experience-dependent plasticity during stroke recovery. Molecular Neurobiology, 55: 2196-2213, 2018.
Filipkowski RK, Kaczmarek L. Severely impaired adult brain neurogenesis in cyclin D2 knock-out mice produces very limited phenotypic changes. Progress in Neuropsychopharmacology & Biological Psychiatry, 80: 63-67, 2018.

2017

Schaefer N, Rotermund C, Blumrich EM, Lourenco MV, Joshi P, Hegemann RU, Jamwal S, Ali N, García Romero EM, Sharma S, Ghosh S, Sinha JK, Loke H, Jain V, Lepeta K, Salamian A, Sharma M, Golpich M, Nawrotek K, Paidi RK, Shahidzadeh SM, Piermartiri T, Amini E, Pastor V, Wilson Y, Adeniyi PA, Datusalia AK, Vafadari B, Saini V, Suárez-Pozos E, Kushwah N, Fontanet P, Turner AJ. The malleable brain: plasticity of neural circuits and behavior – A review from students to students. Journal of Neurochemistry, 142: 790-811, 2017.
Bijata M., Labus J., Guseva D., Stawarski M., Butzlaff M., Dzwonek j., Schneeberg J., Bohm K., Michaluk P., Rusakov D.A., Dityatev A.,Wilczynski G., Wlodarczyk J., Ponimaskin E. Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix. Cell Reports, 19: 1767-1782, 2017.
Lepeta K., Purzycka K., Pachulska-Wieczorek K., Mitjans M., Begemann M., Vafadari B., Bijata K., Adamiak R., Ehrenreich H., Dziembowska M., Kaczmarek L., A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms. EMBO Molecular Medicine, 9: 1100-1116, 2017.
Kaczmarek L. BNST-derived CRF controls binge alcohol drinking via interacting with both CRFR1 and CRFR2 receptors in the VTA. Biological Psychiatry, 81: 905–906, 2017.
Poreba M., Szalek A., Rut W., Kasperkiewicz P., Rutkowska-Wlodarczyk I., Snipas S., Itoh Y., Turk, B., Overall C., Kaczmarek L., Salvesen G., Drag M. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Scientific Reports, 7: 43135, 2017.
Shukla A., Beroun A., Panopoulou M., Neumann P.A., Grant S.G.N., Olive M.F., Dong Y., Schlüter O.M. Calcium-permeable AMPA receptors and silent synapses in cocaine-conditioned place preference. EMBO Journal, 36: 458–474, 2017.
Was H, Barszcz K, Czarnecka J, Kowalczyk A, Bernas T, Uzarowska E, Koza P, Klejman A, Piwocka K, Kaminska B, Sikora E. Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Oncotarget, 8: 9303-9322, 2017.
Stefaniuk M., Beroun A., Lebitko T., Markina O., Leski S., Meyza K., Grzywacz A., Samochowiec J., Samochowiec A., Radwanska K., Kaczmarek L. Matrix metalloproteinase-9 and synaptic plasticity in the central amygdala in control of alcohol seeking behavior. Biological Psychiatry, 81: 907–917, 2017.
Stamenkovic V., Stamenkovic S, Jaworski T, Gawlak M, Jovanovic M, Jakovcevski I, Wilczynski GM, Kaczmarek L, Schachner M, Radenovic L, Andjus PR. The extracellular matrix glycoprotein Tenascin-C and matrix metalloproteinases modify cerebellar structural plasticity by exposure to an enriched environment brain structure and function. Brain Structure & Function, 222: 393–415, 2017.
Kondratiuk I., Leski S., Urbańska M., Biecek P., Devijver H., Lechat B., Van Leuven F., Kaczmarek L., Jaworski T. GSK-3β and MMP-9 cooperate in the control of dendritic spine morphology. Molecular Neurobiology, 54:200–211, 2017.

2016

Roszkowska M, Skupien A, Wójtowicz T, Konopka A, Gorlewicz A, Kisiel M, Bekisz M, Ruszczycki B, Dolezyczek H, Rejmak E, Knapska E, Mozrzymas JW, Wlodarczyk J, Wilczynski GM, Dzwonek J. CD44 – a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines. Molecular Biology of the Cell, 27: 4055-4066, 2016.
Bialy M, Bogacki-Rychlik W, Kasarello K, Nikolaev E, Sajdel-Sulkowska EM. Modulation of 22-khz postejaculatory vocalizations by conditioning to new place: Evidence for expression of a positive emotional state. Behavioral Neuroscience, 130: 415-421, 2016
Zybura-Broda K., Amborska R., Ambrozek-Latecka M., Wilemska J., Bogusz A., Konopka A., Grajkowska W., Roszkowski M., Marchel A., Rysz A., Koperski L., Wilczynski G.M., Kaczmarek L., Rylski M. Epigenetics of epileptogenesis-evoked upregulation of Matrix Metalloproteinase-9 in hippocampus. PLoS One, 11: e0159745, 2016.
Liguz-Lecznar M., Urban-Ciecko J., Kossut M. Somatostatin and somatostatin-containing neurons in shaping neuronal activity and plasticity. Frontiers in Neural Circuits. 10: 48, 2016
Kaczmarek L. MMP-9 in control of synaptic plasticity: A subjective account. Opera Medica et Physiologica, 2: 24-32, 2016.
Lepeta K., Mychael V. Lourenco M.V., Schweitzer3 B.C., Martino Adami P.V., Banerjee P., Catuara-Solarz S., de La Fuente Revenga M., Guillem A.M., Haidar M., Ijomone O.M., Nadorp B., Qi L., Perera N.D., Refsgaard L.K., Reid K.M., 14, Sabbar M., Sahoo A., Schafer N., 17, Sheean R.K., Suska A., Verma R., Vicidomini C., Wright D., Zhang X.-D., Seidenbecher C. Synaptopathies: synaptic dysfunction in neurological disorders. Journal of Neurochemistry, 38: 785-805, 2016.
Stefaniuk M., Gualda E.J., Pawlowska M., Legutko D., Matryba P., Koza P., Konopka W., Owczarek D., Wawrzyniak M., Loza- Alvarez P., Kaczmarek L. Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene. Scientific Reports, 6: 28209, 2016.
Magnowska M., Gorkiewicz T., Suska A., Wawrzyniak M., Rutkowska-Wlodarczyk I., Kaczmarek L., Wlodarczyk J. Transient ECM protease activity promotes synaptic plasticity. Scientific Reports, 6: 27757, 2016.
Mozrzymas J.W., Kaczmarek L. Extracellular proteolysis – a versatile mechanism shaping neuroplasticity. Frontiers in Cellular Neuroscience, 10: 59, 2016.
Vafadari B., Salamian A., Kaczmarek L. MMP-9 in Translation: From Molecule to Brain Physiology, Pathology, and Therapy. Journal of Neurochemistry, 139 Suppl 2: 91-114, 2016.
Jasińska M., Milek J., Cymerman I., Łęski S., Kaczmarek L., Dziembowska M. miR-132 regulates dendritic spine structure by direct targeting of matrix metalloproteinase 9 mRNA. Molecular Neurobiology, 53: 4701–4712, 2016.
Kuzniewska B., Nader K., Dabrowski M., Kaczmarek L., Kalita K. Adult deletion of SRF increases 257. epileptogenesis and decreases activity-induced gene expression. Molecular Neurobiology, 53: 1478–1493, 2016.
Litwiniuk A, Pijet B, Pijet-Kucicka M, Gajewska M, Pająk B, Orzechowski A. FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells. PLoS One, 11: e0146726, 2016.

2015

Goodarzi N, Dabbaghi P, Valipour H, Vafadari B. Pilot Study: The Role of the Hemispheric Lateralization in Mental Disorders by Use of the Limb (Eye, Hand, Foot) Dominance. Basic and Clinical Neuroscience, 6: 101-116, 2015.
Toczyłowska-Mamińska R., Szymona K., Madej H., Wong W.Z., Bala A., Brutkowski W., Krajewski K., H’ng P.S., Mamiński M. Cellulolytic and electrogenic activity of Enterobacter cloacae in mediatorless microbial fuel cell. Applied Energy, 160: 88-93, 2015.
Meloni M., Cesselli D., Caporali A., Mangialardi G., Avolio E., Reni C., Fortunato O., Martini S., Madeddu P., Valgimigli M., Nikolaev E., Kaczmarek L., Angelini G.D., 1, Beltrami A.P., Emanueli C. Cardiac nerve growth factor overexpression induces bone marrow-derived progenitor cells mobilization and homing to the infarcted heart. Molecular Therapy, 23: 1854–1866, 2015.
Wiera G, Szczot M, Wojtowicz T, Lebida K, Koza P, Mozrzymas JW. Impact of matrix metalloproteinase-9 overexpression on synaptic excitatory transmission and its plasticity in rat CA3-CA1 hippocampal pathway. Journal of Physiology and Pharmacology,66: 309-315. 2015
Cymerman IA, Gozdz A, Urbanska M, Milek J, Dziembowska M, Jaworski J. Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3β. PLoS One, 10: e0134018, 2015.
Kondratiuk I., Plucinska G.B., Miszczuk D., Wozniak G., Szydlowska K., Kaczmarek L., Filipkowski R.K., Luikasiuk K., Epileptogenesis following kainic acid-induced status epilepticus in cyclin D2 knock-out mice with diminished adult neurogenesis. PLoS One, 10: e0128285, 2015.
Lepeta K. Kaczmarek L. Matrix metalloproteinase-9 as a novel player in synaptic plasticity and schizophrenia. Schizophrenia Bulletin, 41: 1003-1009.
Gorkiewicz T., Balcerzyk M., Kaczmarek L., Knapska E. Matrix metalloproteinase 9 (MMP-9) is indispensable for long term potentiation in the central and basal but not in the lateral nucleus of the amygdala. Frontiers in Cellular Neuroscience, 9: 73, 2015.
Zayat V, Balcerak A, Korczynski J, Trebinska A, Wysocki J, Sarnowska E, Chmielarczyk M, Macech E, Konopiński R, Dziembowska M, Grzybowska EA. HAX-1: A Novel P-Body Protein. DNA & Cell Biology, 34: 43-54, 2015.

2014

Gawrys L, Falkiewicz M, Pilacinski A, Riegel M, Piatkowska-Janko E, Bogorodzki P, Wolak T, Andrysiak R, Krolicki L, Kulinski R, Koziorowski D, Janik P, Rymarczyk K, Grabowska A, Kaczmarek L, Szatkowska I. The neural correlates of specific executive dysfunctions in Parkinson’s Disease. Acta Neurobiologiae Experimentalis, 74: 465–478, 2014.
Pawłowska M, Goetz S, Dreher C, Wurdack M, Krauss E, Razinskas G, Geisler P, Hecht B, Brixner T Shaping and spatiotemporal characterization of sub-10-fs pulses focused by a high-NA objective. Optics Express, 22: 31496-31510, 2014
Skupien A, Konopka A, Trzaskoma P, Labus J, Gorlewicz A, Swiech L, Babraj M, Dolezyczek H, Figiel I, Ponimaskin E, Wlodarczyk J, Jaworski J, Wilczynski GM, Dzwonek J. CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi apparatus. Journal of Cell Science, 127: 5038-5051.
Bialy M, Strefnel M, Nikolaev-Diak A, Socha A, Nikolaev E, Boguszewski PM. Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment. Epilepsy & Behavior, 39C: 66-72, 2014
van der Kooij M. , Fantin M. , Rejmak E., Grosse J., Zanoletti O., Fournier C., Ganguly K., Kalita K., Kaczmarek L., Sandi C. Role for MMP-9 in stress-induced down-regulation of nectin-3 in hippocampal CA1 and associated behavioral alterations. Nature Communications, 5: 4995, 2014.
Tsilibari E.,Tzinia A., Radenovic L., Stamenkovic V., Lebitko T., Mucha M., Pawlak R., Frischknecht R., Kaczmarek L. Neural ECM proteases in learning and synaptic plasticity. Progress in Brain Research, 214: 135-157, 2014.
Stawarski M., Stefaniuk M., Wlodarczyk J.M. Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines. Frontiers in Neuroanatomy, 8: 68, 2014.
Maurin H, Lechat B, Borghgraef P, Devijver H, Jaworski T, Van Leuven F. Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β. European Journal of Neuroscience, 40: 2442–2453, 2014.
Yeghiazaryan M., Konopka A., Rutkowska-Wlodarczyk I., Wilczynski G.M., Melikyan A., Korkotian E., Kaczmarek L., Figiel I. DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity. PLoS ONE, 9: e99789, 2014.
Jedynak P., Kos T., Sandi C., Kaczmarek L., Filipkowski R.K. Mice with ablated adult brain neurogenesis are not impaired in antidepressant response to chronic fluoxetine. Journal of Psychiatric Research, 56: 106-111, 2014.
Szepesi Z., Hosy E., Ruszczycki B., Bijata M., Pyskaty M., Bikbaev A., Heine M., Choquet D., Kaczmarek L., Wlodarczyk J. Synaptically released matrix metalloproteinase activity in control of structural plasticity and the cell surface distribution of GluA1-AMPA receptors. PLoS ONE, 9: e98274, 2014.
Garthe A., Huang Z., Kaczmarek L., Filipkowski R.K., Kempermann G. Not all water mazes are created equal: Cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits. Genes, Brain and Behavior, 13: 357-364, 2014.
Stawarski M., Rutkowska-Wlodarczyk I., Zeug A., Bijata M., Madej H., Kaczmarek L., Wlodarczyk J. Genetically encoded biosensor for imaging MMP-9 activity. Biomaterials, 35: 1402-1410, 2014.
Chaturvedi M., Molino Y., Bojja S., Khrestchatisky M., Kaczmarek L. Tissue inhibitor of matrix metalloproteinases-1 loaded PLGA nanoparticles for delivery across the blood brain barrier. International Journal of Nanomedicine, 9: 575–588, 2014.
Chaturvedi M., Kaczmarek L., MMP-9 inhibition: A therapeutic strategy in ischemic stroke. Molecular Neurobiology, 49: 563-573, 2014.

2013

Kiryk A., Sowodniok K., Kreiner G., Rodriguez-Parkitna J., Soenmez A., Górkiewicz T., Bierhoff H., Wawrzyniak M., Janusz A.K., Liss B., Konopka W., Schütz G., Kaczmarek L, Parlato R. Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Frontiers in Cellular Neuroscience, 7: 207, 2013.
Janusz A., Milek J., Perycz M., Pacini L., Bagni C., Kaczmarek L., Dziembowska M. The Fragile X Mental Retardation Protein regulates Matrix Metalloproteinase 9 mRNA at synapses. Journal of Neuroscience, 33: 18234–1824, 2013.
Knapska E., Lioudyno V., Kiryk A., Gorkiewicz T., Mikosz M., Michaluk P., Gawlak M., Chaturvedi M., Mochol G., Balcerzyk M., Wojcik D.K., Wilczynski G.M., Kaczmarek L. Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. Journal of Neuroscience, 33: 14591–14600, 2013.
Ben Abdallah N.M.-B., Filipkowski R. K., Pruschy M., Jaholkowski P., Winkler J., Kaczmarek L., and Lipp H.-P. Impaired long-term memory retention: common denominator for acutely or genetically reduced hippocampal neurogenesis in adult mice. Behavioural Brain Research, 252: 275– 286, 2013.
Ganguly K., Rejmak E., Mikosz M., Nikolaev E., Knapska E., Kaczmarek L. Matrix Metalloproteinase (MMP)-9 transcription in mouse brain induced by fear learning. Journal of Biological Chemistry, 288: 20978-20991, 2013.
Dziembowska M., Pretto D.I., Janusz A., Kaczmarek L., Leigh M.J., Gabriel N., Durbin-Johnson B., R.J. Hagerman R.J, Tassone F. High activity levels of MMP-9 in fragile X syndrome are lowered by Minocycline. American Journal of Medical Genetics: Part A. 161: 1897-1903, 2013.
Szepesi Z., Bijata M., Ruszczycki B., Kaczmarek L., Wlodarczyk J. Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation. PLoS One, 8: e63314, 2013.
Kondratiuk I., Devijver H., Lechat B., Van Leuven F., Kaczmarek L., Filipkowski R.K. Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice. Behavioural Brain Research, 248: 46-50, 2013.
Schughart K., Libert C., SYSGENET consortium (incl. Kaczmarek L.), Kas M.J. Controlling complexity: The clinical relevance of mouse complex genetics. European Journal of Human Genetics, 21: 1191-1196,2013.
Kuzniewska B., Rejmak E., Malik A., Jaworski J., Kaczmarek L., Kalita K. Brain-derived neurotrophic factor induces matrix metalloproteinase-9 expression in neurons via serum response factor/c-Fos pathway. Molecular and Cellular Biology, 33: 2149–2162, 2013.
Kaczmarek L. MMP-9 inhibitors in the brain: Can old bullets shoot new targets? Current Pharmaceutical Design,19: 1085-1089, 2013.
A. Walczak, A. Szczepankiewicz, B. Ruszczycki, A. Magalska, K. Zamlynska, J. Dzwonek, E. Wilczek, K. Zybura-Broda, M. Rylski, M. Malinowska, M. Dabrowski, T. Szczepinska, K. Pawlowski, M. Pyskaty, J. Wlodarczyk, I. Szczerbal, M. Switonski, M. Cremer, G. Wilczynski: Novel higher-order epigenetic regulation of the Bdnf gene upon seizures. Journal of Neuroscience, 33: 2507-2511, 2013.
Wiera G., Wozniak G., Bajor M., Kaczmarek L., Mozrzymas J.W. Maintenance of long-term potentiation in hippocampal mossy fiber – CA3 pathway requires fine-tuned MMP-9 proteolytic activity. Hippocampus, 23: 529-543, 2013.
Bajor M., Kaczmarek L., Proteolytic remodeling of the synaptic cell adhesion molecules (CAMs) by metzincins in synaptic plasticity. Neurochemical Research, 38:1113–1121, 2013.
Urbach A., Robakiewicz I., Baum E., Kaczmarek L., Witte O.W., Filipkowski R.K., Cyclin D2 knockout mice with depleted adult neurogenesis learn Barnes maze task. Behavioral Neuroscience, 127: 1-8, 2013.

2012

Knapska E., Macias M., Mikosz M., Nowak A., Owczarek D., Wawrzyniak M., Pieprzyk M., Cymerman I.A., Werka T., Sheng M., Maren S., Jaworski J., Kaczmarek L., Functional anatomy of neural circuits regulating fear and extinction. Proceedings of the National Academy of Sciences USA, 42: 17093-17098, 2012.
Dziembowska M., Milek J., Janusz A., Rejmak E., Romanowska E., Gorkiewicz T., Tiron A., Bramham C., Kaczmarek L. Activity-dependent local translation of matrix metalloproteinase-9. Journal of Neuroscience, 32: 14538–14547, 2012.
Kaliszewska A., Bijata M., Kaczmarek L., Kossut M., Experience-dependent plasticity of the barrel cortex in mice observed with 2-DG brain mapping and c-Fos; effects of MMP-9 KO. Cerebral Cortex, 22: 2160-2170, 2012.
Bajor M., Michaluk P., Gulyassy P., Kekesi A.K., Juhasz G., Kaczmarek L. Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome. Journal of Neurochemistry, 122: 775–788, 2012.
Nowak K, Meyza K, Nikolaev E, Hunt MJ, Kasicki S. Local blockade of NMDA receptors in the rat prefrontal cortex increases c-Fos expression in multiple subcortical regions. Acta Neurobiologiae Experimentalis, 72: 207-218, 2012.
Car H., Michaluk P., Baclofen influences acquisition and MMP-2, MMP-9 levels in the hippocampus of rats after hypoxia. Pharmacological Reports, 64: 536-545, 2012.
Chaturvedi M., Figiel I., Sreedhar B., Kaczmarek L. Neuroprotection from Tissue Inhibitor of Metalloproteinase-1 and its nanoparticles. Neurochemistry International, 61: 1065–1071, 2012.
Ruszczycki B., Szepesi Z., Wilczynski G., Bijata M., Kalita K., Kaczmarek L., Wlodarczyk J. Sampling issues in quantitative analysis of dendritic spines morphology. BMC Bioinformatics, 13: 213, 2012.
Hoehna Y., Uckermann O., Luksch H., Stefovska V., Marlen Theil M.J., Gorkiewicz T., Gawlak M., Wilczynski G.M., Kaczmarek L., Ikonomidou C. Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced status epilepticus in the developing brain. Neurobiology of Disease, 48: 339–347, 2012.
Bukowska D., Ruminski D., Szlag D., Grulkowski I., Wlodarczyk J., Szkulmowski M., Wilczynski G., Gorczynska I., Wojtkowski M., Multi-parametric imaging of murine brain using spectral and time domain optical coherence tomography. Journal of Biomedical Optics 17: 101515, 2012.
Kalita K., Kuzniewska B., Kaczmarek L. MKLs: co-factors of serum response factor (SRF) in neuronal responses. International Journal of Biochemistry & Cell Biology, 1444–1447, 2012.
Yeghiazaryan M, Zybura-Broda K, Cabaj A, Włodarczyk J, Sławińska U, Rylski M, Wilczyński GM. Fine-structural distribution of MMP-2 and MMP-9 activities in the rat skeletal muscle upon training: a study by high-resolution in situ zymography. Histochemistry and Cell Biology, 138: 75–87, 2012.
Loubinoux I., Kronenberg G., Endres M., Schumann-Bard P., Freret T., Filipkowski R.K., Kaczmarek L., Popa-Wagner A. Poststroke depression: mechanisms, translation and therapy. Journal of Cellular and Molecular Medicine, 16: 1961-1969, 2012.
Dziembowska M, Wlodarczyk J. MMP9: a novel function in synaptic plasticity. International Journal of Biochemistry & Cell Biology, 44: 709-713, 2012.
Wiera G., Wójtowicz T., Lebida K., Piotrowska A., Drulis-Fajdasz D., Gomułkiewicz A., Gendosz D., Podhorska-Okołów M., Capogna M., Wilczyński G., Dzięgiel P., Kaczmarek L., Mozrzymas J.W. Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber – CA3 pathway. Molecular and Cellular Neuroscience, 50: 147-159, 2012.
Radwanska K., Kaczmarek L. Characterization of an alcohol addiction-prone phenotype in mice. Addiction Biology, 17: 601-612, 2012.
Jedynak P., Jaholkowski P., Wozniak G., Sandi C., Kaczmarek L., Filipkowski R.K. Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning ability. Behavioural Brain Research, 227: 159–166, 2012.
Bieganska K., Figiel I., Gierej D., Kaczmarek L., Klejman L. Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from Programmed Cell Death. Neurobiology of Disease, 45: 701–710, 2012.

2011

Radwanska K. , Medvedev N.I., Pereira G.S., Engmann O., Thiede N., Moraes M.F.D., Villers A., Irvine E.E., Maunganidze N.S., Pyza E., Ris L., Szymańska M., Lipiński M., Kaczmarek L., Stewart M.G., Giese K.P. A mechanism for long-term memory formation when synaptic strengthening is impaired. Proceedings of the National Academy of Sciences USA, 108: 18471–18475, 2011.
Lukasiuk K., Wilczynski G.M., Kaczmarek L. Extracellular proteases in epilepsy. Epilepsy Research, 96: 191-206, 2011.
Meyza K.Z., Boguszewski P.M., Nikolaev E., Zagrodzka J. Age increases anxiety and reactivity of the fear/anxiety circuit in Lewis rats. Behavioural Brain Research, 225: 192-200, 2011.
Wlodarczyk J., Mukhina I., Kaczmarek L., Dityatev A. Extracellular matrix molecules, their receptors and secreted proteases in synaptic plasticity. Developmental Neurobiology, 71: 1040-1053, 2011.
Leto K., Bartolini A., Di Gregorio A., Imperiale D., de Luca A., Parmigiani E., Filipkowski R.K., Kaczmarek L., Rossi F. Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation, Development, 138: 3463-3472, 2011.
Michaluk P., Wawrzyniak M., Alot P., Szczot M., Wyrembek P., Mercik K., Medvedev N., Wilczek E., DeRoo M., Zuschratter W., Muller D., Wilczynski G.M., Mozrzymas J.W., Stewart M.G., Kaczmarek L., Wlodarczyk J. Influence of matrix metalloproteinase, MMP-9 on dendritic spine morphology. Journal of Cell Science, 124, 3369–3380, 2011.
Jaholkowski P., Mierzejewski P., Zatorski P., Scinska A., Sienkiewicz-Jarosz H., Kaczmarek L., Samochowiec J., Filipkowski R.K., Bienkowski P. Increased ethanol intake and preference in cyclin D2 knockout mice. Genes, Brain and Behavior, 10: 551-556, 2011.
Kiryk A., Mochol G., Filipkowski R.K., Wawrzyniak M., Lioudyno V., Knapska E., Gorkiewicz T., Balcerzyk M., Łęski S., , Van Leuven F., Lipp H.P., Wójcik D.K., Kaczmarek L. Cognitive abilities of Alzheimer’s disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research, 8: 883-892, 2011.
Konopka W., Schütz G., Kaczmarek L. The microRNA contribution to learning and memory. Neuroscientist, 17: 468-474, 2011.
Rybakowski J.K., Skibińska M., Suwalska A., Leszczyńska-Rodziewicz A., Kaczmarek L., Hauser J. Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene and response to lithium prophylaxis in bipolar patients. Human Psychopharmacology Clinical and Experimental, 26: 168-171, 2011.
Bialy M, Nikolaev-Diak A, Kalata U, Nikolaev E. Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats. Physiology and Behavior, 103: 295-301, 2011.
Swiech L., Blazejczyk M., Urbanska M., Pietruszka P., Dortland B.R., Malik A.R., Wulf P.S., Hoogenraad C.C., Jaworski J. CLIP-170 and IQGAP1. Cooperatively Regulate Dendrite Morphology. Journal of Neuroscience, 31: 4555-4568, 2011.
Kiryk A., Pluta R., Figiel I., Mikosz M., Ulamek M., Niewiadomska G., Jablonski M., Kaczmarek L., Transient brain ischemia due to the cardiac arrest causes irreversible long-lasting cognitive injury. Behavioural Brain Research, 219: 1–7, 2011.
Uckermann O., Luksch H., Stefovska V., Hoehna Y., Marzahn J., Theil M., Pesic M., Górkiewicz T., Gawlak M., Wilczynski G.M., Kaczmarek L., Ikonomidou C. Matrix metalloproteinases 2 and 9 fail to influence drug-induced neuroapoptosis in developing rat brain. Neurotoxicity Research, 19:638–648, 2011.

2010

Rivera S., Khrestchatisky M., Kaczmarek L., Rosenberg G.A., Jaworski D.M., Metzincin proteases and their inhibitors, foes or friends in nervous system physiology? Journal of Neuroscience, 30: 15337–15357, 2010.
Konopka W., Kiryk A., Novak M., Herwerth M., Parkitna J.R., Wawrzyniak M., Kowarsch A., Michaluk P., Dzwonek J., Arnsperger T., Wilczynski G.M., Merkenschlager M., Theis F., Kohr G., Kaczmarek L., Schutz G. microRNA loss enhances learning and memory in mice. Journal of Neuroscience, 30: 14835–14842, 2010.
Wisniewska M, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, Klejman M, Dabrowski M, Filipkowski R, Nagalski A, Mozrzymas J, Kuznicki J. LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. Journal of Neuroscience, 30: 4957-4969, 2010.
Woehler A, Wlodarczyk J, Neher E. Signal/noise analysis of FRET-based sensors. Biophysical Journal 99: 2344-2354, 2010.
Klaus Schughart & SYSGENET consortium (Kaczmarek L.), SYSGENET: a meeting report from a new European network for systems genetics. Mammalian Genome, 21:331–336, 2010.
Radwanska K., Tudor-Jones A., Mizuno K., Pereira G., Lucchesi W., Alfano I., Lach A., Kaczmarek L., Knapp S., Giese P. Differential regulation of CaMKII inhibitor a protein expression after exposure to a novel context and during contextual fear memory formation. Genes, Brain and Behavior, 9: 648-657, 2010.
Heuser K, Hoddevik EH, Taubøll E, Gjerstad L, Indahl U, Kaczmarek L, Berg PR, Lien S, Nagelhus EA, Ottersen OP. Temporal lobe epilepsy and matrix metalloproteinase 9: A tempting relation but negative genetic association. Seizure, European Journal of Epilepsy, 19: 335-338, 2010.
Rutkowska-Wlodarczyk I., Kierdaszuk B., Wlodarczyk J. Analysis of proton exchange kinetics with time-dependent exchange rate. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804: 891-898, 2010.
Bialy M., Kalata U., Nikolaev-Diak A., Nikolaev E. D1 receptors involved in the acquisition of sexual experience in male rats. Behavioural Brain Research, 206: 166-176, 2010.
Gorkiewicz T., SzczuraszekK., Wyrembek P., Michaluk P., Kaczmarek L., Mozrzymas J.W. Matrix metalloproteinase-9 (MMP-9) reversibly affects the time course of NMDA-induced currents in cultured rat hippocampal neurons. Hippocampus, 20: 1105–1108, 2010.
Radwanska K.,Nikolaev E., Kaczmarek L., Central noradrenergic lesion by DSP-4 impairs acquisition of avoidance reaction and prevents molecular changes in the amygdala. Neurobiology of Learning and Memory, 94: 303–311, 2010.
Samochowiec A., Grzywacz A., Kaczmarek L., Bienkowski P., Mierzejewski P., Preuss U., Ciechanowicz A., Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: family and case control study. Brain Research, 1327: 103-106, 2010.

2009

Dewachter I., Filipkowski R.K., Priller C., Ris L., Neyton J., Croes S., Terwel D., Gysemans M., Devijver H., Borghgraef P., Godaux E., Kaczmarek L., Herms J., Van Leuven F. Deregulation of NMDA-receptor function and down-stream signaling in APP[V717I] transgenic mice. Neurobiology of Aging, 30: 241-256, 2009.
Gawlak M., Górkiewicz T., Gorlewicz A., Konopacki F.A., Kaczmarek L., Wilczynski G.M., High resolution in situ zymography reveals matrix metalloproteinase activity at glutamatergic synapses, Neuroscience, 158: 167-176, 2009.
Rylski M., Amborska R., Zybura K., Michaluk P., Bielinska B., Konopacki F.A., Wilczynski G.M., Kaczmarek L., JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons. Molecular and Cellular Neuroscience, 40: 98–110, 2009.
Meyza KZ, Boguszewski PM, Nikolaev E, Zagrodzka J. Diverse Sensitivity of RHA/Verh and RLA/Verh Rats to Emotional and Spatial Aspects of a Novel Environment as a Result of a Distinct Pattern of Neuronal Activation in the Fear/Anxiety Circuit. Behavior Genetics , 39: 48-61, 2009.
Rybakowski J.K., Skibinska M., Leszczynska-Rodziewicz A., Kaczmarek L., Hauser J., Matrix metalloproteinase-9 gene modulates prefrontal cognition in bipolar men. Psychiatric Genetics, 19:108–109, 2009.
Woehler A., Wlodarczyk J., Ponimaskin E.G.Specific oligomerization of the 5-HT1A receptor in the plasma membrane. Glycoconjugate Journal, 26: 749-756, 2009.
Konopka,W., Duniec K., Klejman A., Wawrzyniak M., Owczarek D., Gawrys L., Maleszewski M., Mallet J., Kaczmarek L., Tet system in the brain: transgenic rats and lentiviral vectors approach. Genesis, 47: 274-280, 2009
Sarnowska A., Jurga M., Buzanska L., Filipkowski R.K., Duniec K.,Domanska-Janik K. Bilateral interaction between cord blood-derived human neural stem cells and organotypic rat hippocampal culture. Stem Cells and Development, 18: 1191-200, 2009.
Rybakowski J.K., Skibinska M., Kapelski P., Kaczmarek L., Hauser J. Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia Schizophrenia Research, 109: 90–93, 2009.
Gorlewicz A., Wlodarczyk J., Wilczek E., Gawlak M., Cabaj A., Majczynski H., Nestorowicz K., Herbik M.A., Grieb P., Slawinska U., Kaczmarek L., Wilczynski G.M. CD44 is expressed in non-myelinating Schwann cells of the adult rat, and may play a role in neurodegeneration-induced glial plasticity at the neuromuscular junction. Neurobiology of Disease, 34: 245-258, 2009.
Michaluk P., Mikasova L., Groc L, Frischknecht R, Choquet D., Kaczmarek L. Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin b1 signaling. Journal of Neuroscience, 29: 6007– 6012, 2009.
Rybakowski J.K., Borkowska A., Skibinska M., Kaczmarek L., Hauser J. The -1562 C/T polymorphism of the matrix metalloproteinase-9 gene is not associated with cognitive performance in healthy subjects. Psychiatric Genetics, 19:277–278, 2009.
Rybakowski J., Skibinska M., Leszczynska-Rodziewicz A., Kaczmarek L., Hauser J., Matrix metalloproteinase-9 (MMP-9) gene and bipolar mood disorder. NeuroMolecular Medicine, 11:128-132, 2009.
Jaholkowski P., Kiryk A., Jedynak P., Ben Abdallah N.M., Knapska E., Kowalczyk A., Piechal A., Blecharz-Klin K., Figiel I., Lioudyno V., Widy-Tyszkiewicz E., Wilczynski G.M., Lipp H.P., Kaczmarek L., Filipkowski R.K. New hippocampal neurons are not obligatory for memory formation; cyclin D2 knock-out mice with no adult brain neurogenesis show learning. Learning and Memory, 16: 439-451, 2009
Konopacka A., Konopacki F.A., Albrecht J. Protein kinase G is involved in ammonia-induced swelling of astrocytes. Journal of Neurochemistry, 109 (Suppl. 1) 246–251, 2009.
Kvachnina E., Dumuis A., Wlodarczyk J., Renner U., Cochet M., Richter DW., Ponimaskin E. (2009) Constitutive Gs-, but not G12-mediated activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain. Biochmica et Biohysica Acta - Molecular Cell Research, 1793: 1646-1655, 2009
Jaworski T., Dewachter I., Lechat B., Croes S., Termont A., Demedts D., Borghgraef P., Devijver H., Filipkowski R.K., Kaczmarek L., Kügler S., van Leuven F. AAV-Tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PLoS One, 4: e7280, 2009.

2008

Mioduszewska B., Jaworski J., Szklarczyk A.W., Klejman A., Kaczmarek L. Inducible cAMP early repressor (ICER)-evoked delayed neuronal death in the organotypic hippocampal culture. J. Neurosci. Res., 86: 61-70, 2008.
Kiryk A., Aida T., Tanaka K., Banerjee P., Wilczynski G.M., Meyza K., Knapska E., Filipkowski R.K., Kaczmarek L., Danysz W. Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction. Neurotoxicity Res., 13: 19-30, 2008.
Wilczynski G.M., Konopacki F.A., Wilczek E., Lasiecka Z., Gorlewicz A., Michaluk P., Wawrzyniak M., Malinowska M., Okulski P., Kolodziej L.R., Konopka W., Duniec K., Mioduszewska B., Nikolaev E., Walczak A., Owczarek D., Gorecki D.C., Zuschratter W., Ottersen O.P., Kaczmarek L. Important role of matrix metalloproteinase 9 (MMP-9) in epileptogenesis. J. Cell Biol., 180: 1021–1035, 2008.
Gawrys L., Szatkowska I., Jamrozik Z., Janik P., Friedman A., Kaczmarek L. Nonverbal deficits in explicit and implicit memory of Parkinson's disease patients. Acta Neurobiol. Exp., 68: 58–72, 2008.
Wilczek E., Rzepko R., Nowis D., Legat M., Golab J., Glab M., Gorlewicz A., Konopacki F., Mazurkiewicz M., Sladowski D., Gornicka B., Wasiutynski A., Wilczynski G.M. The possible role of factor H in colon cancer resistance to complement attack. Int. J. Cancer., 122: 2030-2037, 2008
Balwierz A., Czech U., Polus A., Filipkowski R.K., Mioduszewska B., Proszynski T., Kolodziejczyk P., Skrzeczynska-Moncznik J., Dudek W., Kaczmarek L., Kulig J., Pryjma J., Dembinska-Kiec A. Human adipose tissue SVF cells differentiate depending on distinct types of media. Cell Prolif., 41: 441-459, 2008.
Macias M. Injury induced dendritic plasticity in the mature central nervous system. Acta Neurobiol Exp., 68: 334-346, 2008.
Urbanska M., Blazejczyk M., Jaworski J. Molecular basis of dendritic arborization. Acta Neurobiol Exp., 68: 264–288, 2008.
Solecki W, Krowka T, Kubik J, Kaczmarek L, Przewlocki R. Role of fosB in behaviours related to morphine reward and spatial memory. Behav. Brain Res., 190: 212-217, 2008.
Fiedorowicz A, Figiel I, Zaremba M, Dzwonek K, Oderfeld-Nowak B. The ameboid phenotype of NG2 (+) cells in the region of apoptotic dentate granule neurons in trimethyltin intoxicated mice shares antigen properties with microglia/macrophages. Glia, 56: 209-222, 2008.
Radwanska K., Wrobel E., Korkosz A., Rogowski A., Kostowski W., Bienkowski P., Kaczmarek L. Alcohol relapse induced by discrete cues activates components of AP-1 transcription factor and ERK pathway in the rat basolateral and central amygdala. Neuropsychopharmacology, 33: 1835-1846, 2008.
Solecki W, Krowka T, Kubik J, Kaczmarek L, Przewlocki R. Increased analgesic tolerance to acute morphine in fosB knock-out mice: A gender study. Pharmacology, Biochemistry and Behavior, 90: 512-516, 2008.
Rylski, M., Amborska A., Zybura K., Konopacki F.A., Wilczynski G.M., Kaczmarek L. Yin Yang 1 expression in the adult rodent brain. Neurochemical Research, 33: 2556-2564, 2008.
Kalita K., Makonchuk D., Gomes C., Zheng J.J. Hetman M., Inhibition of nucleolar transcription as a trigger for neuronal apoptosis. J.Neurochem., 105: 2286-2299, 2008.
Filipek A, Schneider G, Mietelska A, Figiel I, Niewiadomska G. Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein. Journal of Neural Transmission, 115: 1257-1264, 2008.
Fiedorowicz A., Figiel I., Zaremba M., Dzwonek K., Schliebs R., Oderfeld-Nowak B. Trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied with the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, in majority NG2 positive. Brain Research Bulletin, 77: 19-26, 2008.
Walzlein J. H., Synowitz M., Engels B., Markovic D.S., Gabrusiewicz K., Nikolaev E., Yoshikawa K., Kaminska B., Kempermann G., Uckert W., Kaczmarek L., Kettenmann H., Glass R. The anti-tumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells, 26: 2945–2954, 2008.
Gozdz A, Vashishta A, Kalita K, Szatmari E, Zheng JJ, Tamiya S, Delamere NA, Hetman M. Cisplatin-mediated activation of extracellular signal-regulated kinases 1/2 (ERK1/2) by inhibition of ERK1/2 phosphatases. Journal of Neurochemistry, 106: 2056-2067, 2008.
Kharebava G., Makonchuk D., Kalita K., Zheng J.-J., Hetman M. Requirement of 3-phosphoinositide-dependent protein kinase-1 (PDK1) for BDNF-mediated neuronal survival. Journal of Neuroscience, 28: 11409-11420, 2008.
Rylski M., Amborska A., Zybura K., Mioduszewska B., Michaluk P., Jaworski J., Kaczmarek L. Yin Yang 1 is a Critical Repressor of Matrix Metalloproteinase-9 Expression in Brain Neurons. Journal of Biological Chemistry, 283: 35140-35153, 2008.
Kaczmarek L. Neuronal and synaptic plasticity in the brain physiology and pathophysiology. Preface. Journal of Physiology and Pharmacology, 59 (suppl 8): 131-133, 2008.

2007

Meyza K.Z., Boguszewski P.M., Nikolaev E., Zagrodzka J., The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats. Behavioural Brain Research, 180: 183-189, 2007.
Michaluk P., Kolodziej L., Mioduszewska B., Wilczynski G.M., Dzwonek J., Jaworski J., Gorecki D.C., Ottersen O.P., Kaczmarek L., b-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity. J. Biol. Chem., 282:16036-16041, 2007.
Michaluk P., Kaczmarek L., Matrix metalloproteinase-9 (MMP-9) in glutamate-dependent adult brain function and dysfunction, Cell Death and Differentiation, 14:1255-1258, 2007.
Knapska E., Radwanska K., Werka T., Kaczmarek L., Functional internal complexity of amygdala: focus on gene activity mapping following behavioral training and drugs of abuse. Physiological Reviews, 87: 1113-1173, 2007.
Okulski P., Jay T.M., Jaworski J., Duniec K., Dzwonek J., Konopacki F.A., Wilczynski G.M., Sánchez-Capeli A., Mallet J., Kaczmarek L., TIMP-1 abolishes MMP-9-dependent long-lasting LTP in the prefrontal cortex. Biological Psychiatry, 62: 359-362, 2007.
Konopacki F.A., Rylski M., Wilczek E., Amborska R., Detka D., Kaczmarek L., Wilczyński G.M., Synaptic localization of seizure-induced matrix metalloproteinase-9 mRNA. Neuroscience, 150: 31-39, 2007.
Nowis D, Legat M, Bil J, Kurzaj Z, Issat T, Stoklosa T, Mioduszewska B, Kaczmarek L, Jakóbisiak M, Golab J. Erythropoietin reduces cisplatin-induced neurotoxicity without impairment of cytotoxic effects against tumor cells. Int J Oncol. 31: 1547-1552, 2007.
Figiel I, Dzwonek K. TNFalpha and TNF receptor 1 expression in the mixed neuronal-glial cultures of hippocampal dentate gyrus exposed to glutamate or trimethyltin. Brain Res., 1131: 17-28, 2007.

2006

Habas A., G. Kharebava, E. Szatmari, and M. Hetman. NMDA neuroprotection against a Phosphatidylinositol-3 Kinase inhibitor, LY294002 by NR2B-mediated suppression of Glycogen Synthase Kinase-3beta-induced apoptosis. J. Neurochem. 96: 335-348, 2006.
Radwanska, K., Valjent E., Trzaskos J., Caboche J., Kaczmarek L., Regulation of cocaine-induced AP-1 transcription factors by the Extracellular signal-Regulated Kinase (ERK) pathway. Neuroscience, 137: 253-264, 2006.
Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R.M., Silva, A.J., Kaczmarek, L., Huntley, G.W. (2005) Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. J. Neurosci., 26: 1923-1934, 2006.
Knapska E., Nikolaev E., Boguszewski P., Walasek G., Blaszczyk J., Kaczmarek L., Werka T. Between-subject transfer of emotional information evokes specific pattern of amygdala activation. Proc. Natl. Acad. Sci. USA, 103: 3858-3862, 2006.
Knapska A., Walasek G., Nikolaev E., Neuhäusser-WespyF., LippH-P., Kaczmarek L., Werka T. , Differential involvement of the central amygdala in appetitive versus aversive learning. Learn. Mem., 13: 192-200, 2006.
Szymczak S., Kalita K., Jaworski J., Mioduszewska B., Savonenko A., Markowska A., Merchenthaler I., Kaczmarek L. Estrogen Receptor beta regulates synaptic plasticity in the rat hippocampus. Hippocampus, 16: 453-463, 2006.
Detka D., Kalita K., KaczmarekL., Activation function–1 domain plays a negative role in dimerization of estrogen receptor beta. J. Steroid Biochem. Mol. Biol., 99: 157-160, 2006.
Tararuk T., Östman N., Li W., Björkblom B., Padzik A., Zdrojewska J., Hongisto V., Herdegen T., Konopka W., Courtney M.J., Coffey E.T. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J. Cell Biol., 173: 265-277, 2006
Mierzejewski P., Siemiatkowski M., Radwanska K., Szyndler J., Bienkowski P., Stefanski R., Kaczmarek L., Kostowski W., Cycloheximide impairs acquisition but not extinction of cocaine self-administration. Neuropharmacology, 51:367-373, 2006.
Klejman A., Kaczmarek L., Inducible cAMP repressor (ICER) isoforms and neuronal apoptosis in cortical in vitro culture. Acta Neurobiol. Exp., 66: 266-272, 2006.

2005

Klejman A., Węgrzynowicz M., Szatmari E. M., Mioduszewska B., Hetman M., Albrecht J. Mechanism of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione. Neurochem Int, 47: 51-57, 2005.
Kalita K., Szymczak S., Kaczmarek L. Non-nuclear estrogen receptor beta and alpha in the hippocampus of male and female rat. Hippocampus, 15: 404-412, 2005.
Konopka W., Duniec K., Mioduszewska B., Proszynski T., Jaworski J., Kaczmarek L. hCMV and Tet promoters for the inducible gene expression in rat neurons in vitro and in vivo. Neurobiology of Disease, 19: 283-292, 2005.
Filipkowski R.K., Kiryk A., Kowalczyk A., Kaczmarek L. Genetic models to study adult neurogenesis. Acta Biochim. Polon., 52 , 359-372, 2005.
Radwanska K., Caboche J., Kaczmarek L. Extracellular Signal-Regulated Kinases (ERKs) modulate cocaine-induced gene expression in the mouse amygdala. Eur. J. Neurosci.,22: 939-948, 2005.
E.Szatmari, A.Habas, P.Yang, J.J.Zheng, T.Hagg and M.Hetman. A positive feedback loop between glycogen synthase kinase 3beta and protein phosphatase 1 after stimulation of NR2B NMDA receptors in forebrain neurons. J. Biol. Chem. 280: 37526-37535, 2005.
Pláteník J., Balcar V.J., Yoneda Y., Mioduszewska B., Buchal R., Hynek R., Killianek L., Kuramoto N., Wilczynski G., Ogita K., Nakamura Y., Kaczmarek L. Apparent presence of Ser133-phosphorylated cyclic AMP response element binding protein (pCREB) in brain mitochondria is due to cross-reactivity of pCREB antibodies with pyruvate dehydrogenase. J. Neurochem., 95: 1446-1460, 2005.

2004

Rylski M., Kaczmarek L., AP-1 targets in the brain, Front. Biosci., 9: 8-23, 2004.
Bienkowski P., Rogowski A., Korkosz A., Mierzejewski P., Radwanska K., Kaczmarek L., Bogucka-Bonikowska A., Kostowski W., Time-dependent changes in alcohol-seeking behaviour during abstinence European Neuropsychopharmacology, 14: 355-360, 2004.
Skrzypczak M., Zagulska-Szymczak S., Lidereau R., Bieche I., Lewandowski S., Radwanska K., Szczylik C., Vidaud M., Boyer B., Jakowicki J.A., Kaczmarek L., Evaluation of mRNA expression of ERb and its isoforms in human normal and neoplastic endometrium. Int. J. Cancer, 11: 783-787, 2004.
Dzwonek J., Rylski M. Kaczmarek L., Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in neuronal physiology of the adult brain. FEBS Lett., 567: 129-135, 2004.
Frankland P.W., Bontempi B., Talton L.E., Kaczmarek L., Silva A.J.The involvement of the anterior cingulate cortex in remote contextual fear memory. Science, 304: 881-883, 2004.
Hetman M, Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. European Journal of Biochemistry, 271: 2050-2055, 2004.
Hetman M, Gozdz A. Role of extracellular signal regulated kinases in neuronal death and survival. European Journal of Biochemistry, 271: 2049, 2004.
Korkosz A., , Kolomanska P., Kowalska K., Rogowski A., Radwanska K., Kaczmarek L., Mierzejewski P., Scinska A., Kostowski W., Bienkowski P., Dissociation of ethanol and saccharin preference in fosB knockout mice Physiol. Behav., 82: 391-395, 2004.
Knapska E., Kaczmarek L., A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK? Prog. Neurobiol., 74: 183-211, 2004.
Kowalczyk A., Filipkowski RK, Rylski M., Wilczynski G.M., Konopacki F.A., Jaworski J., Ciemerych M.A., Sicinski P., Kaczmarek L. The critical role of cyclin D2 in adult neurogenesis. J. Cell Biol., 167: 209-213, 2004.

2003

Jaworski J., Mioduszewska B., Sanchez-Capelo A., Figiel I., Habas A. Gozdz A., Proszynski T. Hetman M., Mallet J., Kaczmarek L. Inducible cAMP Early Repressor, an endogenous antagonist of cAMP responsive element binding protein evokes neuronal apoptosis in vitro. J. Neurosci., 23: 4519-4526, 2003.
Sacharczuk M., Jaszczak K., Sadowski B. The relationship between stress and sensitivity to mutagens in two mouse lines selected for high and low analgesia. Mut. Res. Genet.Toxicol. Environment. Mutagen, 535: 95-102, 2003.
Sacharczuk M., Jaszczak K., Sadowski B. Chromosomal NOR Activity in Mice Selected for High and Low Swim Stress-Induced Analgesia. Behav. Genet., 33: 435-441, 2003.
Savonenko, A., Werka, T.,Nikolaev, E., Zieliński, K., Kaczmarek, L. Complex effects of NMDA receptor antagonist APV in basolateral of amygdala on acquisition of two-way active avoidance reeaction and long-term fear memory. Learn. Mem., 10: 293-303, 2003.
Gozdz A., Habas A., Jaworski J., Zielinska M., Albrecht J., Chlystun M., Jalili A., Hetman M. Role of N-methyl-D aspartate receptors in the neuroprotective activation of Extracellular Signal Regulated Kinase1/2 by Cisplatin. J.Biol. Chem., 278: 43663-43671, 2003.
Mioduszewska B., Jaworski J., Kaczmarek L. Inducible cAMP early repressor (ICER) in the nervous system - a transcriptional regulator of neuronal plasticity and programmed cell death. J. Neurochem., 87: 1313-1320, 2003.
Lazowski K.W., Kaczmarek L. Short, 12 mer fluorescently labelled methylphosphonated oligonucleotides to visualize beta-actin mRNA in vivo. Journal of Physiology and Pharmacology 54: 611-623, 2003.

2002

Szklarczyk A., Lapinska J., Rylski M., McKay R.D.G., Kaczmarek L. Matrix metalloproteinase -9 undergoes expression and activation during dendritic remodeling in adult hippocampus. J. Neurosci., 22: 920-930, 2002.
Rivera S., Ogier C., Jourquin J., Timsit S., Szklarczyk A., Miller K., Gearing A.J.H., Kaczmarek L., Khrestchatisky M. Gelatinase B and TIMP-1 are regulated in a cell- and time dependent manner in association with cell demise, neuroinflammation and repair processes after global forebrain ischemia. Eur. J. Neurosci., 15: 19-32, 2002.
Okulski P., Hess G., Kaczmarek L. Anisomycin treatment paradigm affects duration of LTP in the slices of amygdala, Neuroscience, 114: 1-5, 2002.
Lewandowski S., Kalita K., Kaczmarek L., Estrogen receptor beta. Potential functional significance of a variety of mRNA isoforms. FEBS Lett., 524: 1-5, 2002.
Nikolaev E., Kaczmarek L., Zhu S.W., Winblad W., Mohammed A.H. Environmental manipulation differentially alters c-Fos expression in amygdaloid nuclei following aversive conditioning. Brain Res., 957: 91-98, 2002.
Kaczmarek L., Lapinska-Dzwonek J., Szymczak S., Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections? EMBO J., 21: 6643-6648, 2002.
Radwanska K., Nikolaev E., Knapska E., Kaczmarek L. Differential response of two subdivisions of lateral amygdala to aversive conditioning as revealed by c-Fos and P-ERK mapping. NeuroReport, 13: 2241-2246, 2002.
Hetman M., Hsuan S-L., Habas A., Higgins M.J., Xia Z. Extracellular Signal Regulated Kinase 1/2 Antagonizes Glycogen Synthase Kinase 3b–Induced Apoptosis in Cortical Neurons. J. Biol. Chem., 277: 49577-49584, 2002.
Jachner A., Rydz M.A. Behavioural response of roach (Cyprinidae) to different doses of chemical alarm cues (Schrekstoff). Arch. Hydrobiol., 155: 369-381, 2002.
Filipek A., Jastrzebska B., Nowotny M., Kwiatkowska K., Hetman M., Surmacz L., Wyroba E., Kuznicki J. Ca2+-dependent Translocation of the Calcyclin-binding Protein in Neurons and Neuroblastoma NB-2a Cells. J. Biol. Chem., 277: 21103-21109, 2002.

2001

Zagulska-Szymczak, S., Filipkowski, R., Kaczmarek, L. Kainate-induced genes in the hippocampus: lessons from expression patterns. Neurochem. Int. 38: 485 -501, 2001.
Sabala P., Czajkowski R., Przybylek K., Kalita K., Kaczmarek L., Baranska J. Two subtypes of G protein-coupled nucletide receptors, P2Y1 and P2Y2 are involved in calcium signalling in glioma C6 cells. Brit. J. Pharmacol., 132: 393-402, 2001.
Filipkowski R.K., Rydz M., Kaczmarek L., Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior. Neuroscience, 106: 679-688, 2001.

2000

Kaczmarek L. Gene expression in learning processes, Acta Neurobiol. Exp., 60: 419-424, 2000.
Filipkowski R.K. Inducing gene expression in barrel cortex - focus on immediate early genes. Acta Neurobiol. Exp., 60: 411-418, 2000.
Filipkowski R.K., Rydz M., Berdel B., Morys J, Kaczmarek L. Tactile experience induces c-Fos expression in rat barrel cortex. Learning and Memory, 7: 116-122, 2000.
Lazowski K., Kaczmarek L., Detection of hybridization of oligonucleotides to specific sequences of nucleic acids by application of fluorescence resonance energy transfer. Antisense Nucl. Acids Drug Dev., 10: 97-103, 2000.
Jaworski J., Figiel I., Proszynski T., Kaczmarek L., Efficient expression of tetracycline-responsive gene following transfection of dentate gyrus neurons in vitro. J. Neurosci. Res., 60: 754-760, 2000.
Jastrzebska B., Filipek A., Nowicka D., Kaczmarek L., Kuznicki J., Calcyclin (S100A6) Binding Protein (CacyBP) is highly expressed in brain neurons. J. Histochem. Cytochem., 48: 1195-1202, 2000.
Bialy M., Rydz M., Kaczmarek L., Precontact 50-kHz vocalizations in male rats during acquisition of sexual experience. Behav. Neurosci., 114: 983-990, 2000.
Zajaczkowski W., Hetman M., Nikolaev E., Quack G., Danysz W., Kaczmarek L., Behavioural evaluation of long-term neurotoxic effects of NMDA receptor antagonists. Neurotoxicity Res., 1: 299-310, 2000.

1999

Lukasiuk K., Savonenko A., Nikolaev E., Rydz M., Kaczmarek L., Defensive conditioning-related increase in AP-1 transcription factor in the rat cortex. Mol. Brain Res., 67: 64-73, 1999.
Kaczmarek L., Zangenehpour S., Chaudhuri A. Sensory regulation of immediate-early genes c-fos and zif268 in monkey visual cortex at birth and throughout the critical period. Cerebral Cortex, 9: 179-187, 1999.
Górecki D.C., Szklarczyk A., Lukasiuk K., Kaczmarek L., Simons J.P. Differential seizure-induced and developmental changes of neurexin expression. Mol. Cell. Neurosci. 13: 218-227, 1999.
Kaminska B., Kaczmarek L., Zengenehpour S., Chaudhuri A., Rapid phosphorylation of Elk-1 transcription factor and activation of MAP kinase transduction pathways in response to visual stimulation. Mol. Cell. Neurosci., 13: 405-414, 1999.
Savonenko A., Filipkowski R.K., Werka T., Zielinski K, Kaczmarek L. Defensive conditioning-related functional heterogeneity among nuclei of rat amygdala revealed by c-Fos mapping. Neuroscience, 94: 723-733, 1999.
Jaworski J., Biedermann I.W., Lapinska J., Szklarczyk A., Figiel I, Konopka D., Nowicka D., Filipkowski R.K., Hetman M., Kowalczyk A., Kaczmarek L., Neuronal excitation-driven and AP-1-dependent activation of timp-1 gene expression in rodent hippocampus. J. Biol. Chem., 274: 28106-28112, 1999.
Szklarczyk A.W., Kaczmarek. Brain as a unique antisense environment. Antisense Nucl. Acids Drug Dev., 9: 105-116, 1999.

1998

Dabrowski M., Robinson E., Hughes S.V., Bland R. and Hewison M. Differential RNA display identifies novel genes associated with decreased vitamin D receptor expression. Mol Cell Endocrinol., 142, 131-139, 1998.
Frankland P.W., Cestari V., Filipkowski R.K., McDonald R.J., Silva A.J. The dorsal hippocampus is essential for context discrimination but not for contextual conditioning, Behav. Neurosci. 112, 863-74, 1998.
Giese K.P., Fedorov N.B., Filipkowski R.K., Silva A.J., Autophosphorylation at Thr286 of the calcium calmodulin kinase II in LTP and learning. Science, 279: 870-873, 1998.
Gorecki D.C., Lukasiuk K., Szklarczyk A.W., Kaczmarek L., Kainate-evoked changes in dystrophin mRNA levels in the rat hippocampus. Neuroscience, 84: 467-477, 1998.
Konopka, D., Szklarczyk, A.W., Filipkowski, R.K., Trauzold, A., Nowicka, D., Hetman, M., Kaczmarek, L. Plasticity- and neurodegeneration-linked CREM/ICER mRNA expression in the rat brain. Neuroscience, 86: 499-510, 1998.

1997

Hetman, M., Danysz W., Kaczmarek L. Increased expression of Cathepsin D in retrosplenial cortex of MK-801-treated rats. Exp. Neurol., 147: 229-237, 1997.
Figiel I., Kaczmarek L., Orthovanadate induces cell death in rat dentate gyrus primary culture. NeuroReport, 8: 2465-2470, 1997.
Kaminska B., Kaczmarek L., Larocque S., Chaudhuri A., Activity-dependent regulation of cytochrome b expression in monkey visual cortex. J. Comp. Neurol., 379: 271-282, 1997.
Figiel I., Kaczmarek L. Cellular and molecular correlates of glutamate-evoked neuronal programmed cell death in the in vitro culture of rat hippocampal dentate gyrus. Neurochem. Int., 31: 229-240, 1997.
Zielinski K., Nikolaev E., Changes of intertrial response rate with elapse of time after two-way avoidance trial in rats. Acta Neurobiol. Exp., 57: 41-47, 1997.
Gorecki D.C., Abdulrazzakj H., Lukasiuk K., Barnard E.A. Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain. Eur. J. Neurosci., 9, 965-976, 1997.
Szklarczyk A., Kaczmarek L. Pharmacokinetics of antisense analogues in the central nervous system, Neurochem. Int., 31: 413-423, 1997.
Kaminska B., Filipkowski R.K., Biedermann I.W., Konopka D., Nowicka D., Hetman M., Dabrowski M., Gorecki D., Lukasiuk K., Szklarczyk A.W., Kaczmarek L. Kainate-evoked modulation of gene expression in rat brain. Acta Biochim. Polon., 44: 781-789, 1997.
Kaczmarek L., Chaudhuri A., Sensory regulation of immediate-early gene expression in mammalian visual cortex: Implications for functional mapping and neural plasticity. Brain Res. Rev., 23: 237-256, 1997.
Kaczmarek L., Kossut M., Skangiel-Kramska J.Glutamate receptors in cortical plasticity: molecular and cellular biology. Physiol. Rev., 77: 217-255, 1997.

1996

Nowicka D., Kaczmarek L., Spatio-temporal pattern of NMDA receptor NR1 mRNA expression during postnatal development of visual structures of the rat brain. J. Neurosci. Res., 44:471-477, 1996.
Kaminska B., Kaczmarek L., Chaudhuri A. Visual stimulation regulates the expression of transcription factors and modulates the composition of AP-1 in rat visual cortex. J. Neurosci., 16: 3968-3978, 1996.
Szklarczyk A., Blaszczyk J., Kaczmarek L. Antisense oligonucleotides against transcription factor Zif 268 transiently impair excitatory transmission in the hippocampus without affecting Zif 268 immunoreactivity. Neurosci. Res. Commun., 19: 125-133, 1996.
Bialy M., Kaczmarek L., c-fos expression as a tool to search for the neurobiological basis of the sexual behavior of males. Acta Neurobiol. Exp., 56: 567-577, 1996.

1995

Zablocka B; Lukasiuk K; Lazarewicz JW; Domanska-Janik K. Modulation of ischemic signal by antagonists of N-methyl-D-aspartate, nitric-oxide synthase, and Platelet-Activating-Factor in gerbil hippocampus. J. Neurosci. Res., 40: 233-240, 1995.
Kaczmarek L. Towards understanding of the role of transcription factors in learning processes. Acta Biochim. Polon., 42: 221-226, 1995.
Konopka D., Nowicka D., Filipkowski R.K., Kaczmarek L., Kainate-evoked secondary gene expression in the rat hippocampus. Neurosci. Lett., 185: 167-170, 1995.
Lukasiuk K., Kaczmarek L., Condorelli D.F., Transcription factors NF-kB DNA binding activities in rat brain cells cultured in vitro. Neurochem. Int., 26: 173-178, 1995.
Szklarczyk A., Kaczmarek L., Antisense oligodeoxyribo-nucleotides: stability and distribution after intra-structure injection into rat brain. J. Neurosci. Meth., 60: 181-187, 1995.
Przewlocki R., Kaminska B., Lukasiuk K., Nowicka D.Z., Przewlocka B., Kaczmarek L., Lason W. Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus. Neuroscience, 68: 73-81, 1995.
Kaminska B., Mosieniak G., Gierdalski M., Kossut M., Kaczmarek L., Elevated AP-1 transcription factor DNA binding activity at the onset of functional plasticity during development of rat sensory cortical areas. Mol. Brain Res.,33: 295-304, 1995.
Hetman M., Filipkowski R.K., Domagala W., Kaczmarek L., Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration. Exp. Neurol., 136: 53-63, 1995.

1994

Nikolaev E., Kaczmarek L., Disruption of two-way active avoidance behavior produced by nimodipine. Pharmacol. Biochem. Behav., 47: 757-759, 1994.
Condorelli D.F., Dell`Albani P., Amico C., Lukasiuk K., Kaczmarek L., Condorelli D.F., Giuffrida-Stella A.M., Glutamate- receptor driven activation of transcription factors in primary neuronal cultures. Neurochem. Res., 19: 489-499, 1994.
Lukasiuk K., Kaczmarek L., AP-1 and CRE DNA binding activities nin rat brain following pentylenetetrazole induced seizures. Brain Res., 643: 227-233, 1994.
Kaminska B., Filipkowski R.K., Zurkowska G., Lason W., Przewlocki R., Kaczmarek L., Dynamic changes in composition of AP-1 transcription factor DNA binding activity in rat brain following kainate induced seizures and cell death. Eur. J. Neurosci., 6: 1558-1566, 1994.
Filipkowski R.K., Hetman M., Kaminska B., Kaczmarek L. DNA fragmentation in rat brain after intraperitoneal administration of kainate. NeuroReport, 5: 1538-1540, 1994.
Kaczmarek L., Glutamate-evoked gene expression in brain cells - Focus on transcription factors. Amino Acids, 7: 245-254, 1994.
Kaminska B., Lukasiuk K., Kaczmarek L. Seizures-evoked activation of transcription factors. Acta Neurobiol. Exp., 54: 65-72, 1994.
Popov B., Kaczmarek L., Antibody raised to the short sequence from the zinc-finger domain of the Egr-1 recognizes 102 kD protein in mouse fibroblasts. Biochem. Mol. Biol. Int., 32: 39-47, 1994.

1993

Condorelli, D.F., Dell Albani P., Amico C., Kaczmarek L., Nicoletti F., Lukasiuk, K., Giuffrida-Stella A.M. Induction of primary response genes by excitatory amino acids receptor agonists in primary astroglial cultures. J. Neurochem., 60: 877-885, 1993.
Kaczmarek L., Molecular biology of vertebrate learning: is c-fos a new beginning? J. Neurosci. Res., 34: 377-381, 1993.
Kaczmarek L., L-glutamate-driven gene expression in learning. Acta Neurobiol. Exp., 53: 187-196, 1993.
Kaminska, B., Kaczmarek L., Robust induction of AP-1 transcription factor DNA binding activity in the hippocampus of aged rats. Neurosci. Lett., 153: 189-191, 1993.
Figiel I., Poninski P., Lukasiuk K., Kaczmarek L. Studies on effects of culture conditions and age of donor on hippocampal neurons in vitro. Folia Histochem. Cytobiol., 31: 169-173, 1993.
Zielinski, K; Werka, T; Nikolaev, E latency of the 2-way avoidance-response in rats - inhibition of delay. Acta Neurobiologiae Experimentalis, 53: 535-545, 1993.

1992

Kaminska B., Kaczmarek L., Malaguarnera L., Arcidiacono A., Messina L., Spampinato G., Messina A. Transcription factor activation and functional stimulation of human monocytes. Cell Biol. Int. Rep., 16: 37-45, 1992.
Nikolaev E., Werka T., Kaczmarek L. c-fos protooncogene expression in rat brain after long term training of two-way active avoidance reaction. Behav. Brain Res., 48: 91-94, 1992.
Nikolaev E., Kaminska B., Tischmeyer W., M., Matthies H., Kaczmarek L. Induction of expression of genes encoding transcription factors in rat brain elicited by behavioral training. Brain Res. Bull., 28: 479-484, 1992
Kaminska B., Kaczmarek L., Grzelakowska-Sztabert B. Inhibitors of polyamines biosynthesis affect the expression of genes encoding cytoskeletal proteins. FEBS Lett., 304: 198-200, 1992.
Kaczmarek L., Kaminska B., Messina L., Spampinato G., Arcidiacono A., Malaguarnera L., Messina A. Inhibitors of polyamine biosynthesis block TNF-induced activation of macrophages. Cancer Res., 52: 1891-1894, 1992.
Bialy M., Nikolaev E., Beck J., Kaczmarek L., Delayed c-fos expression in sensory cortex following sexual learning in male rats. Mol. Brain Res., 14: 352-356, 1992.
Czarny M., Sabala, P., Ucieklak,A., Kaczmarek L., Baranska J. Inhibition of phosphatidylserine synthesis by glutamate, acetylocholine, thapsigargin and ionophore A23187 in glioma C6 cells, Biochem. Biophys. Res. Commun., 186: 1582-1587, 1992.
Messina L., Spampinato G., Arcidiacono A., Maslaguarnera L., Pagano M., Messina A., Kaminska B., Kaczmarek L. Polyamine involvement in functional activation of human macrophages. J. Leuk. Biol. 52: 585-587, 1992.
Sikora, E., Kaminska, B., Radziszewska, E., Kaczmarek L. Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo. FEBS Lett., 312: 179-182, 1992.
Kaczmarek L., Expression of c-fos and other genes encoding transcription factors in long term potentiation. Behav. Neur. Biol., 57: 263-266, 1992.

1991

Zielinski, K; Werka, T; Nikolaev, E intertrial responses of rats in 2-way avoidance-learning to visual and auditory-stimuli. Acta Neurobiologiae Experimentalis, 51: 71-88, 1991
Nikolaev E., Tischmeyer W., Krug M., Matthies H., Kaczmarek L., c-fos protooncogene expression in rat hippocampus and entorhinal cortex following tetanic stimulation of the perforant path. Brain Res., 560: 346-349, 1991.
Sierocinska J., Nikolaev E., Danysz W., Kaczmarek L., Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats. Eur. J. Pharmacol., 205: 109-11, 1991.

1990

Kaczmarek L., Nikolajew E., c-fos protooncogene expression and neuronal plasticity. Acta Neurobiol. Exp., 50: 173-179, 1990.
Condorelli D.F., Dell Albani P., Kaczmarek L., Messina L., Spampinato G., Avola R., Messina A., Giuffrida Stella A.M., Glial fibrillary acidic protein messenger RNA and glutamine synthetase activity after nervous system injury. J. Neurosci. Res.,26: 251-257, 1990.
Kaminska B., Kaczmarek L., Grzelakowska-Sztabert B., The regulation of G0-S transition in mouse T lymphocytes by polyamines. Exp. Cell Res., 191: 239-245, 1990.
Messina L., Arcidiacono A., Spampinato G., Malaguarnera L., Berton G., Kaczmarek L., Messina A., Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/ macrophages. FEBS Lett., 268: 32-34, 1990.
Tishmeyer W., Kaczmarek L., Strausss M., Jork R., Matthies H., Accumulation of c-fos mRNA in rat hippocampus during acquisition of a brightness discrimination. Behav. Neural Biol. 54: 165-171, 1990.

1989

Nowak R., Siedlecki J.A., Kaczmarek L., Zmudzka B.Z., Wilson S.H., Levels and size complexity of DNA polymerase b mRNA in rat regenerating liver and other organs. Biochim. Biophys. Acta, 1008: 203-207, 1989.
Condorelli D.F., Kaczmarek L., Nicoletti F., Arcidiacono A., Dell Albani P., Ingrao F., Magri G., Malaguarnera L., Avola R., Messina A., Giuffrida Stella A.M., Induction of protooncogene c-fos by extracellular signals in primary astroglial cell cultures. J. Neurosci. Res.,23: 234-239, 1989.
Kuznicki J., Filipek A., Heimann P., Kaczmarek L., Kaminska B., Tissue specific distribution of calcyclin - 10.5 kDa Ca binding protein. FEBS Lett., 254: 141-144, 1989.
Kaczmarek L., Kaminska B., Molecular biology of cell activation. Exp. Cell Res., 183: 24-35, 1989.
Kaczmarek L., Michalkiewicz J., Fedorowicz M., Wozniewicz B., Thymic non-lymphoid cells cultured for tranplantation purposes. Immunostimulatory effect on ataxia telangiectasia peripheral blood mononuclear cells. Arch. Immun. Ther. Exp., 37: 471-480, 1989.

1988

Kaczmarek L., Siedlecki J.A., Danysz W., Protooncogene c-fos induction in rat hippocampus. Mol. Brain Res., 3: 183-186, 1988.
Kaczmarek L., Ratajczak M.Z., Wiktor-Jedrzejczak W., Postirradiation recovery of haemopoiesis in Steel mutant mice. Int. J. Radiat. Biol., 53: 703-708, 1988.

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2021-2023 NCBiR | Zastosowanie inhibitora metaloproteazy macierzowej do opracowania innowacyjnej metody terapeutycznej zapobiegania rozwojowi padaczki pourazowej i poudarowej, Konkurs "Szybka ścieżka dla Mazowsza" we współpracy z firmą Pikralida (POIR 2014-2020), (L. Kaczmarek)
2020-2024 NCN OPUS | Zrozumieć nawrót alkoholowy przez obrazowanie całego mózgu (M. Stefaniuk)
2019-2022 NCN OPUS | Rola białek MKL w regulacji ekspresji genów, rozwoju synaps i chorób neurorozwojowych (K. Kalita)
2018-2023 Fundacja na rzecz Nauki Polskiej | BRAINCITY – CENTRUM DOSKONAŁOŚCI W ZAKRESIE NEUROPLASTYCZNOŚCI I CHORÓB MÓZGU, partner strategiczny European Molecular Biology Laboratory (EMBL)
2018-2023 NCN MAESTRO | Udział metaloproteazy MMP-9i plastyczności synaptycznej: badania pojedynczych kolców dendrytycznych (L. Kaczmarek)
2018-2022 Narodowe Centrum Badań i Rozwoju (NCBiR) | ERA-NET MISST, Multi-scale investigation of synaptic dysfunction after stroke (L. Kaczmarek; koordynator: V. Nagerl)
2016-2021 Fundacja na rzecz Nauki Polskiej | Pursuing addiction: appetitive learning and synaptic plasticity in the amygdala, Program TEAM (POIR), (L. Kaczmarek)
2018-2021 NCN SONATA | Lokalizacja sygnałów Ca2+ zaangażowanychi uwalnianie glioprzekaźników (P. Michaluk)

2016-2021 NCN SONATA BIS | Plastyczność interneuronów somatostatynowychi parwalbuminowych zachodząca pod wpływem uczenia się: mechanizmyi znaczenie (J. Urban-Ciećko)
2016-2019 NCN SONATA | Wybiórcze blokowanie aktywności receptora NMDAR podczas epileptogenezy, jako podejście terapeutycznei leczeniu padaczki skroniowej (A. Gorlewicz)
2016-2019 NCN OPUS | Rola plastyczności strukturalnej kolców dendrytycznychi uczeniui pamięci (T. Jaworski)
2016-2019 NCN OPUS | Mapowanie pozytywnychi negatywnych wspomnieńi mózgu (M. Pawłowska)
2016-2019 NCN PRELUDIUM | Badanie roli Lipokaliny-2 i nieprawidłowych procesach plastyczności neuronalnej (M. Doliwa)
2015-2018 Narodowe Centrum Badań i Rozwoju (NCBiR) | Inhibitory MMP-9 jako nowy lek blokujący rozwój padaczki (wspólnie OncoArendi Therapeutics, koordynator L. Kaczmarek)
2013-2018 NCN SONATA BIS | Rola białka Serum Response Factor (SRF)i regulacji plastyczności homeostatycznej (K. Kalita)
2015-2017 Narodowe Centrum Badań i Rozwoju (NCBiR) | Nowa terapia zaburzeń psychotycznych orazi chorobie Huntigtona ze szczególnym uwzględnieniem deficytów poznawczych (korodynator CelonPharma). Horizon 2020 ITN ECMED Extracellular matrix in prognostication and treatment of epileptogenesis 2015-2019 (koordynator: M. Walker)
2014-2017 NCN PRELUDIUM 5 | Cięcie nektyny-3 pod wpływem aktywności neuronalnej (E. Rejmak-Kozicka)
2014-2016 NCN PRELUDIUM 5 | Zastosowanie fotoprzełączajacego się TIMP-1 do zbadania wpływu układu MMP-9/TOMP-1 na morfologię kolców dendrytycznych (M. Chaturvedi)
2014-2015 NCN PRELUDIUM 5 | Mechanizmy regulacji MMP-9-GSK3i neuronach (I. Kondratiuk)
2013-2016 NCN OPUS 4 | Komórkowe i molekularne podstawy zaburzeń neurogenezy u dorosłych myszy bez cykliny D2 (A. Czupryn)
2013-2017 7 PR UE ITN EXTRABRAIN | Extracellular brain proteolysis in neuronal plasticity and neuropsychiatric disorders (L. Kaczmarek, koordynator, partnerzy: A. Dityatev, Magdeburg, P. Caroni, Bazylea, D. Rusakov, Londyn, H. Ehrenreich, Getynga, A. Triller, Paryż, R. Pawlak, Exeter, J. Herms, Monachium, O. Flores, Lizbona, K. Young, Hamburg, BUMA, Szwajcaria) http://www.extrabrainitn.eu/
2013-2015 FNP POMOST | Role of Lipocalin 2 in the structural plasticity of neurons (K. Kalita)
2013-2016 NCN HARMONIA | Rola białka FMRPi lokalnej translacji metaloproteinazy macierzy zewnątrzkomórkowej-9i neuronach (M. Dziembowska).
2013-2016 ERANET | Neuron Proteolytic remodeling of the extracellular matrix in aberrant synaptic plasticity underlying epilepsy evoked by traumatic brain injury (L. Kaczmarek, koordynator; partnerzy: A. Pitkanen, Kuopio, O. Tenovuo, Turku, S. Dedeurwaerdere, Antwerpia)
2012-2015 FNP TEAM | MMP-9 driven extrasynaptic proteolysis in physiological and pathological synaptic plasticity (finansowane ze środków POIG UE) (L. Kaczmarek)
2012-2017 NCN SONATA | Model do badania plastyczności synaptycznej oparty na optogenetyce (T. Jaworski)

Udział metaloproteazy MMP-9 w plastyczności synaptycznej

Zmiany siły połączeń pomiędzy komórkami nerwowymi są podstawą zdolności adaptacyjnej mózgu do zmieniających się warunków otoczenia, np. w zjawiskach uczenia się i pamięci. Podłożem tych zmian jest tzw. plastyczność synaptyczna. Mechanizmy molekularne odpowiedzialne za zmiany plastyczne synaps pobudzających, które ulokowane są na komórkach nerwowych na tzw. kolcach dendrytycznych, są jeszcze słabo poznane i stanowią pole bardzo intensywnych badań.

Zrozumienie tych mechanizmów ma z oczywistych powodów podstawowe znaczenia dla poznania funkcjonowania mózgu, a w szczególności relacji mózg-umysł, w warunkach fizjologicznych, w tym i takich zjawiskach, jak uczenie się i pamięć. Równocześnie poznanie mechanizmów plastyczności synaptycznej uważane jest za klucz do zrozumienia istoty najpoważniejszych chorób mózgu. Trzeba tu nadmienić, że badania genetyczne u ludzi pokazały znaczenie polimorfizmów i mutacji w genach kodujących białka synaps pobudzających i kolców dendrytycznych dla rozwoju chorób psychicznych. Warte szczególnego podkreślenia są w tym kontekście olbrzymie koszty społeczne i finansowe – ocenia się, że w krajach Unii Europejskiej te drugie wynoszą 800 mld euro rocznie, w tym 500 mld euro pochłaniają choroby psychiczne. Zainicjowane przez nas 15 lat temu badania nad zewnątrzkomórkowym enzymem proteolitycznym – MMP-9 pokazały, że może on odgrywać znaczącą rolę w zjawiskach plastyczności synaptycznej. Podejrzewamy, że dzieje się tak w wyniku udziału MMP-9 w kontroli przebudowy kolców dendrytycznych. Celem niniejszego projektu jest weryfikacja tej hipotezy. Badania będą prowadzone na hodowlach neuronalnych, w których pojedyncze synapsy zostaną pobudzone poprzez lokalne uwolnienie neuroprzekaźnika – glutaminianu. Planujemy zbadać, w jakich warunkach i na jakich kolcach (które mogą mieć różny kształt i wielkość, co ma związek z ich funkcją) MMP-9 jest wydzielane i może wykazywać swoją aktywność. Postulujemy bezpośredni związek pomiędzy MMP-9 i dobrze już poznanym czynnikiem zaangażowanym w kontrolę plastyczności, BDNF i zamierzamy m.in. sprawdzić, czy MMP-9 może aktywować BDNF na zewnątrz synapsy, poprzez częściowe trawienie jego formy latentnej i uwolnienie aktywnej. Proponowane badania powinny wnieść zupełnie nową wiedzę w kilku obszarach: (1) w dziedzinie poznania mechanizmów działania MMP-9 na poziomie synapsy, co może prowadzić do wykorzystania tej wiedzy w terapii chorób psychicznych; (2) w zakresie zrozumienia mechanizmów molekularnych plastyczności synaptycznej, dodając tutaj całkowicie nowy, zewnątrzkomórkowy wymiar regulacji tego zjawiska; (3) dla rozwoju funkcjonalnej konektomiki (odkrywania sieci połączeń i ich modyfikacji czynnościowej pod wpływem przetwarzania informacji), dostarczając i weryfikując nowe, potencjalnie bardzo atrakcyjne narzędzie badawcze w postaci znacznika fluorescencyjnego (aktywna MMP-9 i jej biosensor) synaps podlegających długotrwałym zmianom plastycznym.

Udział metaloproteazy MMP-9 w plastyczności synaptycznej

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GRUPY BADAWCZE

Pracownia Neurobiologii

Kierownik

Leszek Kaczmarek

Bogna Badyra

Sajad Shabhazi

Karolina Protokowicz

Iwona Sirocka

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